Blood test for detecting HPV-related gynecologic cancers

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate a blood test designed to detect circulating tumor-specific HPV DNA in women diagnosed with high-grade cervical dysplasia or cervical cancer. By utilizing digital droplet polymerase chain reactions (PCR), the test seeks to quantify fragments of tumor-specific DNA shed by HPV-associated cancer cells. The goal is to provide a non-invasive method for screening and monitoring these conditions, potentially reducing the need for invasive procedures. The collaboration with Naveris, a molecular diagnostics company, enhances the study's approach to improving gynecologic cancer care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

All patients above age 18, with biopsy proven HPV-related high-grade cervical dysplasia or invasive cervical cancer will be included.

Exclusion Criteria:

Persons who do not meet the above inclusion criteria.

Where it's running

• Lenox Hill Hospital
  New York, New York, United States Recruiting

Study contacts

• Study coordinator: Elena Pereira, MD
• Email: epereira2@northwell.edu
• Phone: 2124343770

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using liquid biopsies to monitor treatment in HPV-related cancers

  This study tests if using liquid biopsies can help track treatment progress and detect any return of HPV-related cancers, like cervical and throat cancer, in patients.

  Recruiting The Institute of Molecular and Translational Medicine, Czech Republic · Olomouc · NCT05774561

• Detecting gynecologic cancers using DNA markers in vaginal fluid and blood

  This study is testing a new way to detect endometrial, ovarian, and cervical cancers early by looking for specific DNA markers in the vaginal fluid and blood of women with abnormal bleeding.

  Recruiting at 21 sites Mayo Clinic · Phoenix, Arizona and 24 other locations · NCT05051722

• Self-sampling to improve cervical cancer screening attendance

  This study is testing if sending self-sampling kits by mail, through gynecologists, or general practitioners can help more women in the Czech Republic get screened for cervical cancer.

  Recruiting The Institute of Molecular and Translational Medicine, Czech Republic · Olomouc · NCT04226313

• Screening for anal cancer in women with vulvar lesions

  This study is testing if screening for anal cancer with Pap smears can help women over 40 who have vulvar lesions catch any problems early and improve their health.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT03061435

• Cervical screening and care options for women living with HIV who test positive for high-risk HPV

  This study tests different ways to screen and manage high-risk HPV in women with HIV to see what might work best for them.

  Recruiting University of California, San Diego · Nairobi · NCT07925307

• Hydrogel spacer to protect the rectum during cervical cancer radiotherapy

  This study tests whether placing an absorbable hydrogel spacer between the cervix/vagina and rectum before definitive radiotherapy can reduce rectal radiation exposure for women with cervical cancer.

  Recruiting Tianjin Medical University Cancer Institute and Hospital · Tianjin, Tianjin Municipality · NCT07904182

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.