Blood oxytocin response to music enhanced by sonic augmentation
Official title: Plasma Oxytocin Changes in Response to Music Modified by Sonic Augmentation Technology vs Unaugmented Control Music in Healthy Controls and Patients With AVP-Deficiency
Run by University Hospital, Basel, Switzerland · NCT07276152 · Data updated 2026-11-12
This trial will test whether music modified by sonic augmentation can raise blood oxytocin levels in healthy adults and adults with AVP-deficiency.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 22 (estimated) |
| Sponsor | University Hospital, Basel, Switzerland Academic / other |
| Locations | 1 site (Basel) |
| Status | Recruiting |
| Started | January 9, 2026 |
| Main results expected | August 2026 |
| Study ends | August 2026 |
| Registry record updated | February 13, 2026 |
| Trial ID | NCT07276152 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults (≥18) who are either healthy with no regular medications apart from hormonal contraception or have a confirmed diagnosis of AVP-deficiency and can attend in-person sessions.
✕Probably not a fit
People with current or prior major psychiatric disorders, recent heavy substance or alcohol use, high tobacco use, pregnant or breastfeeding individuals, or those on disqualifying medications are unlikely to benefit or be eligible.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study uses a sonic augmentation system to modify musical stimuli and measures plasma oxytocin before and after standardized listening sessions. The protocol includes two parts: healthy adult controls (no regular medications except hormonal contraception) and adults with a confirmed diagnosis of arginine vasopressin (AVP) deficiency. Participants attend controlled sessions at the clinic with blood draws and monitoring for side effects. The aim is to detect short-term changes in plasma oxytocin with minimal to no adverse effects.
Why it matters
Potential benefit: If successful, this could offer a simple, non-drug way to boost oxytocin that might support social bonding or symptom management in people with AVP-deficiency.
How similar studies have gone: Small prior studies have shown that music can raise oxytocin levels, but using dedicated sonic augmentation technology is a novel approach with limited prior data.
Who can join: the full rules
Show full inclusion / exclusion criteria
Part 1: Inclusion Criteria: * Adult healthy controls * No medication, except hormonal contraception Exclusion Criteria: * Participation in a trial with investigational drugs within 30 days * Illicit substance use (except for cannabis) more than 10 times in lifetime or any time within the previous two months * Consumption of alcoholic beverages \>15 drinks/week * Tobacco smoking \>10 cigarettes/day * Current or previous major psychiatric disorder (e.g., major depression, schizophrenia spectrum disorder) * Psychotic disorder in first-degree relatives * Pregnancy and breastfeeding Part 2: Inclusion Criteria: * Confirmed diagnosis of AVP-Deficiency * Age ≥ 18 years Exclusion Criteria: * Participation in a trial with investigational drugs within 30 days * Illicit substance use (except for cannabis) more than 10 times in lifetime or any time within the previous two months * Consumption of alcoholic beverages \>15 drinks/week * Tobacco smoking \>10 cigarettes/day * Current or previous major psychiatric disorder (e.g., major depression, schizophrenia spectrum disorder) * Psychotic disorder in first-degree relatives * Pregnancy and breastfeeding
Where it's running
-
University Hospital Basel
Basel, Switzerland Recruiting
Study contacts
- Principal investigator: Mirjam Christ-Crain, Prof. — University Hospital, Basel, Switzerland
- Study coordinator: Mirjam Christ-Crain, Prof.
- Email: Mirjam.Christ-Crain@usb.ch
- Phone: +41 61 265 25 25
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.