Blood biomarkers to help diagnose invasive mucormycosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is an observational, hospital-based cohort study using venous blood samples to search for uncommon monosaccharides and oligo/polysaccharides from Mucorales cell walls as potential diagnostic markers. The study enrolls confirmed mucormycosis cases and two control groups: high-risk patients without active infection (pre-transplant assessment) and patients with other invasive fungal infections. Samples will be analyzed in specialized laboratories using biochemical and molecular methods and results compared across groups to determine marker specificity and timing. The goal is to identify whether these cell-wall-derived markers appear reliably in blood early enough to aid clinical decision-making.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Men and women
* Age : Children and adults from 3 to 64 years old (18 to 64 for controls)
* In patients whose consent has been collected after information. In the case of children, information on the study will be given to the holders of parental authority and then to the child to obtain their consent.
* Patient social insured
* Specific medical conditions :

  1. For the case group :

     Any patient hospitalized in one of the departments of the University Hospital of Lille, in which the diagnosis of mucormycosis was conducted on the following criteria:
     * Conventional mycology data and / or
     * Positivity of q-PRC and / or
     * Anatomopathologic diagnosis Associated with a compatible clinical situation
  2. For the control group 1 Patient assessed for hematopoietic stem cell transplantation, considered at risk for IFI but for whom the pre-transplantation review will have excluded an ongoing infection
  3. For control group 2 Any patient hospitalized in a department of Lille University Hospital, in which the diagnosis of disseminated candidiasis or invasive pulmonary aspergillosis has been made according to specific classifications (EORTC/MSG criteria, AspICU criteria)

Exclusion Criteria:

* Patients for whom the inclusion criteria are not met
* Co-infection mucormycosis/other IFI

Where it's running

• University Hospital of Lille
  Lille, Hauts-de-France, France Recruiting

Study contacts

• Principal investigator: Marjorie CORNU, MD — University Hospital, Lille
• Study coordinator: Marjorie CORNU, MD
• Email: marjorie.cornu@chru-lille.fr
• Phone: 0320445962

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.