Blood analysis of patients with chronic joint diseases receiving low dose radiation therapy
Immunophenotyping From Blood of Patients Suffering From Chronic Degenerating Joint Diseases and Receiving Local Low Dose Radiation Therapy (LDRT)
This study is testing if low dose radiation therapy can help people with chronic joint diseases feel less pain and move better when other treatments haven't worked.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 250 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Erlangen-Nürnberg Medical School Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Erlangen, Bavaria) |
| Trial ID | NCT02653079 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients suffering from chronic degenerating joint diseases who are receiving low dose radiation therapy (LDRT). It aims to assess the effectiveness of LDRT in reducing pain and improving mobility in patients who have not responded well to conventional treatments. Participants will undergo blood draws and complete questionnaires to evaluate their condition and treatment outcomes. The study seeks to gather data on the molecular and cellular responses to LDRT in these patients.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older diagnosed with specific chronic degenerating joint conditions such as painful shoulder syndrome, elbow syndrome, and various forms of arthritis.
Not a fit: Patients with a history of malignant diseases or those unable to comply with the study protocol may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a new therapeutic option for patients suffering from chronic joint pain, improving their quality of life.
How similar studies have performed: Previous studies have shown promising results with low dose radiation therapy for chronic joint diseases, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients suffering and diagnosed for: * painful shoulder syndrome (periarthritis humeroscapularis) * painful elbow syndrome (Epicondylopathia humeri) * benign achillodynia * benign calcaneodynia * arthosis (finger- , rhiz-, gon-, and anklearthrosis * arthritis (gon- and anklearthrosis) * Planned local low dose radiation therapy (LDRT) at the Department of Radiation Oncology, Universitätsklinikum Erlangen. * Age at least 18 years Exclusion Criteria: * patients who are suffering or had suffered from any malignant diseases * fertile patients who refuse effective contraception during study treatment * persistent drug and/or alcohol abuse * patients not able or willing to behave according to study protocol * patients in care * patients that are not able to speak German
Where this trial is running
Erlangen, Bavaria
- Department of Radiation Oncology, Universitätsklinikum Erlangen — Erlangen, Bavaria, Germany (Recruiting)
Study contacts
- Principal investigator: Oliver J Ott, MD — Department of Radiation Oncology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg
- Study coordinator: Benjamin Frey, PhD
- Email: benjamin.frey@uk-erlangen.de
- Phone: +49 9131 85 44248
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.