BLa80 and LRa05 probiotics and blood metabolite changes in healthy adults

Effects of BLa80 and LRa05 on the Gut Microbiota Metabolite Profile of Healthy Individuals: A Randomized, Double-Blind, Placebo-Controlled Trial

This test will see if taking the probiotics BLa80 or LRa05 changes how healthy adults break down and absorb food, as shown by metabolites in the blood.

Quick facts

• Phase: NA
• Study type: Interventional
• Enrollment: 375 (estimated)
• Ages: 18 Years to 60 Years
• Sex: All
• Sponsor: Wecare Probiotics Co., Ltd. (industry)
• Locations: 1 site (Guangzhou, Guangdong)
• Trial ID: NCT07287306 on ClinicalTrials.gov

What this trial studies

This interventional study enrolls healthy adults aged 18–60 and assigns them to receive BLa80, LRa05, or placebo. Blood samples will be analyzed using metabolomics to identify food-derived metabolites and compare changes between groups. Key exclusions include recent antibiotic or probiotic use and major gastrointestinal, metabolic, immune, cardiac, liver, neurological, or psychiatric conditions. The research requires in-person visits at The First Affiliated Hospital, Sun Yat-sen University for dosing and sample collection.

Who should consider this trial

Good fit: Healthy adults 18–60 who can give written informed consent and who have not taken antibiotics or probiotics in the prior 3 months are ideal candidates.

Not a fit: People with gastrointestinal disease, recent antibiotic or probiotic use, major metabolic, immune, cardiac, liver, neurological, or psychiatric disorders, pregnant or breastfeeding women, or those on immunosuppressants are unlikely to benefit or be eligible.

Why it matters

Potential benefit: If successful, the probiotics could improve breakdown and absorption of dietary compounds and increase beneficial blood metabolites.

How similar studies have performed: Some prior studies have shown that specific probiotic strains can alter gut metabolite profiles, but effects are strain-dependent and not consistently reproduced.

Eligibility criteria

Inclusion Criteria:

1. Male or female participants aged 18 to 60 years;
2. Healthy individuals;
3. Participants must provide written informed consent.

Exclusion Criteria:

1. History of gastrointestinal surgery, other gastrointestinal diseases, metabolic disorders, immunodeficiency, hyperthyroidism, or cardiac or liver disease;
2. Use of immunosuppressants;
3. Pregnant or breastfeeding women;
4. Participants who have taken antibiotics or probiotics within the previous 3 months;
5. Planned surgery during the study period;
6. Patients with neurological disorders or psychiatric illness.

Where this trial is running

Guangzhou, Guangdong

• The First Affiliated Hospttal, Sun Yat-sen University — Guangzhou, Guangdong, China (RECRUITING)

Conditions: Healthy Individuals