Biportal endoscopic decompression versus decompression with fusion for degenerative lumbar spondylolisthesis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective cohort in which patients with degenerative lumbar spondylolisthesis choose either dual-channel (biportal) endoscopic decompression or lumbar decompression with fusion, with standardized surgical protocols and detailed perioperative documentation. Baseline and postoperative pain and neurological function are measured using VAS, JOA, and ODI scores, and imaging with MRI/CT is collected. Operative details (duration, blood loss, intraoperative findings) and tissue specimens are recorded, and patients are followed at 1, 3, 6, 12, 24, and 36 months to compare pain relief, functional recovery, and complication rates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged between 50 and 90 years old with a confirmed diagnosis of degenerative lumbar spondylolisthesis;
2. Clinical symptoms include chronic pain, nerve compression, or motor dysfunction, confirmed by imaging studies (e.g., MRI or CT);
3. No significant improvement after at least 3 months of conservative treatment (e.g., medication, physical therapy), meeting surgical indications;
4. Understand and consent to the relevant procedures of this study, and sign the informed consent form.

Exclusion Criteria:

1. Patients exhibiting acute spinal cord compression symptoms or requiring urgent surgical intervention;
2. Patients with a history of spinal surgery or conditions such as spinal deformities, severe osteoporosis, or active infections that may compromise surgical outcomes;
3. Patients with severe comorbidities affecting assessment, such as cardiovascular disease, liver or kidney failure, or uncontrolled diabetes;
4. Patients with psychiatric disorders or cognitive impairments preventing understanding or cooperation with the study process;
5. Patients with allergies to anesthetics or surgical equipment that may increase intraoperative risks.

Where it's running

• 4th Affiliated Hospital, School of Medicine, Zhejiang University
  Yiwu, Zhejiang, China Recruiting

Study contacts

• Study coordinator: xiang xue, MD
• Email: xuexiang@zju.edu.cn
• Phone: +86 057989935990

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.