Bipolar TURP versus MOSES‑assisted Holmium laser enucleation for enlarged prostate

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional trial compares two surgical approaches for BPH: MOSES‑augmented HoLEP using the Lumenis Pulse 120H with contemporary single‑use MOSES 2.0 fibers and modern morcellation versus bipolar transurethral resection of the prostate (Bi‑TURP). Men meeting symptom, flow, and prostate volume criteria (IPSS 8–35, flowmetry or urodynamic obstruction, prostate 40–80 cc) will undergo one of the procedures and have perioperative metrics recorded. Primary and secondary outcomes include hospital stay, transfusion and complication rates, operative time, and functional outcomes such as IPSS and maximum urinary flow. The trial focuses on current generation laser/morcellator technology to re‑evaluate differences previously reported with older equipment.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with maximum flow rate \< 15 ml/sec before obstructive surgery or with maximum flow rate \> 15 ml/sec and urodynamic study showing high-flow obstruction defined as bladder outlet obstruction index \> 40.
* Patients with moderate to severe lower urinary tract symptoms (LUTS) according to the International Prostate Symptom Score (IPSS). Score between 8 and 35.
* Patients with a prostate volume between 40 and 80 cc, measured by urological ultrasound or MRI.

Exclusion Criteria:

* History of prior prostatic obstructive or urethral surgery.
* Diagnosis of prostate neoplasia.
* Diagnosis of urothelial neoplasia.
* Lack of flowmetry or IPSS data before surgery.
* Diagnosis or suspicion of hypo/acontractile detrusor before prostatic obstructive surgery.
* Diagnosis or suspicion of neurogenic bladder or neurological disease.
* History of pelvic radiation therapy.

Where it's running

• Complejo Hospitalario Universitario de Santiago de Compostela
  Santiago de Compostela, A Coruña, Spain Recruiting
• Fundacio Puigvert
  Barcelona, Barcelona, Spain Recruiting
• Hospital Universitario Marqués de Valdecillas
  Santander, Cantabria, Spain Recruiting
• Hospital Universitario de Cabueñes
  Gijón, Principality of Asturias, Spain Recruiting
• Hospital Universitario Río Hortega
  Valladolid, Valladolid, Spain Recruiting
• Hospital Univesitari de Bellvitge
  L'Hospitalet de Llobregat, Barcelona, Spain Not yet recruiting

Study contacts

• Principal investigator: Ivan Schwartzmann Jochamowitz, MD — Fundacio Puigvert
• Study coordinator: Ivan Schwartzmann Jochamowitz, MD
• Email: ischwartzm@fundacio-puigvert.es
• Phone: 0034934169700

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating alpha-blocker therapy for managing urinary symptoms after prostate surgery

  This study is testing if the medication Tamsulosin can help men feel better by reducing painful and bothersome urinary symptoms after prostate surgery.

  Recruiting Ankara Training and Research Hospital · Ankara · NCT06865430

• Adaptive radiotherapy for localized prostate cancer

  This study is testing a new type of radiation therapy for men with localized prostate cancer who have urinary problems to see if it can safely treat their cancer without causing too many side effects.

  Recruiting University of Zurich · Heidelberg, Baden-Wurttemberg and 2 other locations · NCT06834152

• Comparing two laser techniques for prostate surgery

  This study is testing which of two laser surgery techniques works better for men with medium to large prostates who need help with urinary problems.

  Recruiting at 3 sites Fundacio Puigvert · Barcelona, BARCELONA and 2 other locations · NCT06565741

• Comparing robotic and laser surgery for prostate enlargement treatment

  This study is testing whether robotic surgery or laser surgery is better for treating men with prostate enlargement who haven't found relief from other treatments.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT06224218

• Comparing two treatments for benign prostatic hyperplasia

  This study is testing whether a new procedure called Prostate Artery Embolization works better than the traditional surgery for treating enlarged prostate symptoms in men.

  Recruiting Uppsala University · Helsingborg, Region Skånes and 3 other locations · NCT05531240

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.