Biopsychosocial factors linked to chronic post‑traumatic pain after ICU care
Official title: The Biopsychosocial Model to Identify Risk Factors for Chronic Post-traumatic Pain in ICU Patients
Run by University Hospital, Montpellier · NCT07491354 · Data updated 2026-11-12
This project tries to see if clinical details, blood BDNF levels, treatments, and psychosocial factors during hospitalization can predict which adult polytrauma ICU patients will develop chronic post‑traumatic pain.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | University Hospital, Montpellier Academic / other |
| Locations | 1 site (Montpellier) |
| Status | Recruiting |
| Started | July 29, 2024 |
| Main results expected | July 29, 2027 |
| Study ends | July 29, 2027 |
| Registry record updated | March 24, 2026 |
| Trial ID | NCT07491354 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (≥18 years) with polytrauma, an Abbreviated Injury Scale (AIS) score >1, and at least one documented fracture who are hospitalized in the participating ICU are ideal candidates.
✕Probably not a fit
Patients with only an isolated carpal fracture, isolated traumatic brain injury, isolated minor facial trauma, isolated digestive trauma, or patients under 18 are unlikely to benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers follow adult polytrauma patients admitted to the ICU and record injury characteristics, treatment data, and psychosocial measures during hospitalization. Residual peripheral blood samples are collected from admission to discharge to measure brain‑derived neurotrophic factor (BDNF) while medical records provide clinical and therapeutic information. Patients are reassessed for post‑traumatic symptoms and pain outcomes at 3 and 6 months to identify chronic pain (pain persisting >3 months). The team will integrate clinical, biological, therapeutic, and psychosocial data to build a convergent model aimed at predicting risk of pain chronification before hospital discharge.
Why it matters
Potential benefit: If successful, this could allow clinicians to identify patients at high risk for chronic post‑traumatic pain before discharge so they can receive targeted prevention and follow‑up.
How similar studies have gone: Previous studies have linked BDNF and psychosocial factors to chronic pain and used multidimensional risk models, but no widely validated predictive model for post‑traumatic chronic pain currently exists.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients aged 18 years or older * Patients with an Abbreviated Injury Scale (AIS) score greater than 1 * Patients presenting with at least one documented fracture Exclusion Criteria: * Patients with an isolated fracture of the carpal bones * Patients with isolated traumatic brain injury * Patients with isolated minor facial trauma * Patients with isolated digestive trauma
Where it's running
-
Department of Anesthesiology and critical care, Lapeyronie University Hospital
Montpellier, France Recruiting
Study contacts
- Study coordinator: Sophie Bringuier, PhD
- Email: s-bringuierbranchereau@chu-montpellier.fr
- Phone: +33467338661
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.