Biopsychosocial factors linked to chronic post‑traumatic pain after ICU care
The Biopsychosocial Model to Identify Risk Factors for Chronic Post-traumatic Pain in ICU Patients
University Hospital, Montpellier · NCT07491354
This project tries to see if clinical details, blood BDNF levels, treatments, and psychosocial factors during hospitalization can predict which adult polytrauma ICU patients will develop chronic post‑traumatic pain.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University Hospital, Montpellier (other) |
| Locations | 1 site (Montpellier) |
| Trial ID | NCT07491354 on ClinicalTrials.gov |
What this trial studies
Researchers follow adult polytrauma patients admitted to the ICU and record injury characteristics, treatment data, and psychosocial measures during hospitalization. Residual peripheral blood samples are collected from admission to discharge to measure brain‑derived neurotrophic factor (BDNF) while medical records provide clinical and therapeutic information. Patients are reassessed for post‑traumatic symptoms and pain outcomes at 3 and 6 months to identify chronic pain (pain persisting >3 months). The team will integrate clinical, biological, therapeutic, and psychosocial data to build a convergent model aimed at predicting risk of pain chronification before hospital discharge.
Who should consider this trial
Good fit: Adults (≥18 years) with polytrauma, an Abbreviated Injury Scale (AIS) score >1, and at least one documented fracture who are hospitalized in the participating ICU are ideal candidates.
Not a fit: Patients with only an isolated carpal fracture, isolated traumatic brain injury, isolated minor facial trauma, isolated digestive trauma, or patients under 18 are unlikely to benefit from this protocol.
Why it matters
Potential benefit: If successful, this could allow clinicians to identify patients at high risk for chronic post‑traumatic pain before discharge so they can receive targeted prevention and follow‑up.
How similar studies have performed: Previous studies have linked BDNF and psychosocial factors to chronic pain and used multidimensional risk models, but no widely validated predictive model for post‑traumatic chronic pain currently exists.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients aged 18 years or older * Patients with an Abbreviated Injury Scale (AIS) score greater than 1 * Patients presenting with at least one documented fracture Exclusion Criteria: * Patients with an isolated fracture of the carpal bones * Patients with isolated traumatic brain injury * Patients with isolated minor facial trauma * Patients with isolated digestive trauma
Where this trial is running
Montpellier
- Department of Anesthesiology and critical care, Lapeyronie University Hospital — Montpellier, France (RECRUITING)
Study contacts
- Study coordinator: Sophie Bringuier, PhD
- Email: s-bringuierbranchereau@chu-montpellier.fr
- Phone: +33467338661
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Post Traumatic Chronic Pain, Post traumatic Chronic Pain, Intensive Care Units, Biopsychosocial model