Biomarkers and Gastric Motility Index to Predict Feeding Intolerance in Critically Ill Adults
Official title: Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients: the BGM-FI Study
Run by The First Hospital of Jilin University · NCT07178626 · Data updated 2026-11-12
This observational study tests whether certain biomarkers and gastric motility measurements can predict feeding intolerance in critically ill adults who cannot eat by mouth but may start tube feeding within 48 hours in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 160 (estimated) |
| Sponsor | The First Hospital of Jilin University Academic / other |
| Locations | 1 site (Changchun) |
| Status | Recruiting |
| Started | October 20, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | September 3, 2026 |
| Trial ID | NCT07178626 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with multiple organ system failure, anticipated ICU stay >48 hours, who cannot take oral nutrition but can start enteral feeding within 48 hours, and have no contraindications to enteral nutrition.
✕Probably not a fit
Patients who recover quickly or do not develop feeding intolerance may not show a clear biomarker or motility difference.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this study, researchers will collect serum biomarkers of gastrointestinal injury and assess gastric antral motility using ultrasound after a small amount of water is placed in the stomach. Measurements are taken within 24 hours of ICU admission and before starting enteral nutrition, with serial monitoring for feeding intolerance over the next 7 days. The study is observational and does not involve an experimental intervention beyond biomarker collection and ultrasound assessment. Eligible participants are adults with organ failure, expected ICU stay over 48 hours, and no contraindication to enteral nutrition. The primary aim is to see if the biomarker panel and antral motility index correlate with the development of feeding intolerance.
Why it matters
Potential benefit: If successful, it could help clinicians identify patients at higher risk of feeding intolerance earlier and tailor nutrition plans accordingly.
How similar studies have gone: Prior work has explored biomarkers and GI motility in critical illness, but this exact combination for predicting enteral feeding intolerance is not yet proven.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Presence of one or more organ system failures within 24 hours of ICU admission (SOFA score ≥2) * Expected ICU stay \>48 hours * Inability to take oral nutrition * No contraindications to enteral nutrition (EN) Exclusion Criteria: * Patients who have already received enteral nutrition prior to gastric antral motility measurement or biomarker collection * Receiving palliative care with expected death within 48 hours * Pregnancy * Participation in another clinical trial
Where it's running
-
The First Hospital of Jilin University
Changchun, China Recruiting
Study contacts
- Study coordinator: Dong Zhang Dong Zhang
- Email: zhangdong@jlu.edu.cn
- Phone: +86 15584299391
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.