Biomarker screening to detect early femoral head osteonecrosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Osteonecrosis of the femoral head (ONFH) often progresses quickly to femoral head collapse and may require total hip arthroplasty. This observational project will collect blood samples and clinical data from adults aged 18–70 with diagnosed or suspected ONFH seen in the orthopedic outpatient department of a tertiary Grade A hospital. Investigators will test previously reported candidate blood biomarkers using diagnostic and differential analyses to identify markers with strong diagnostic validity and reliability. The overall aim is to find biomarkers that improve early diagnosis and reduce misdiagnosis rates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Aged between 18 and 70 years old (inclusive).
2. Patients with suspected ONFH.
3. Those who provide informed consent and volunteer to participate in this study.

Exclusion Criteria:

1. Patients with a clear history of hip trauma.
2. Patients with ONFH secondary to traumatic factors such as femoral neck fracture and hip dislocation.
3. Patients complicated with severe mental illness or cognitive impairment who are unable to cooperate with questionnaire completion.
4. Patients who refuse to sign the informed consent form.

Where it's running

• The First Affiliated Hospiatl of Henan Medical University
  Xinxiang, Henan, China Recruiting

Study contacts

• Study coordinator: Wenjie Ren
• Email: 157121431@qq.com
• Phone: 8618937302619

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.