Biological database for understanding atrial fibrillation and stroke
Biological Bank for Studies Related to Atrial Fibrillation and Stroke
This study is collecting blood samples from people with atrial fibrillation and stroke to see if their genes can help us find better treatments for these conditions.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Hospices Civils de Lyon Academic / other |
| Locations | 5 sites (Bourg-en-Bresse and 4 other locations) |
| Trial ID | NCT03611816 on ClinicalTrials.gov |
What this trial studies
This observational study aims to establish a biological bank to investigate the genetic factors associated with atrial fibrillation (AF) and its link to stroke. By collecting blood samples from patients with a history of AF and stroke, the study seeks to identify genetic determinants that could lead to new therapeutic targets. The research focuses on understanding the genetic heterogeneity of AF and its contribution to thromboembolic processes. The findings could provide insights into more effective treatments for these conditions.
Who should consider this trial
Good fit: Ideal candidates include individuals with a history of atrial fibrillation or stroke, as well as those scheduled for electrophysiological exploration or AF ablation.
Not a fit: Patients without a history of atrial fibrillation or stroke, as well as those who are pregnant or unable to provide consent, may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved therapies for patients with atrial fibrillation and stroke by identifying genetic factors that influence these conditions.
How similar studies have performed: Other studies have shown success in identifying genetic factors related to atrial fibrillation and stroke, suggesting that this approach could yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Group 1a * Inclusion Criteria : \- AF history * Exclusion Criteria : * No AF history * patient who didn't signed consent Group 1b * Inclusion Criteria : * AF history * Scheduled electrophysiological exploration or AF ablation * Exclusion Criteria : * No AF history * pregnant women * patient who didn't signed consent Group 1c * Inclusion Criteria : * AF/AT history * Stroke history * Exclusion Criteria : * No Stroke history * patient who didn't signed consent Group 2 * Inclusion Criteria : * patient over 80 * ECG: sinusal rhythm * TTE : no left atrial dilatation * Exclusion Criteria : * atrial fibrillation history * TTE : Left atria \>25cm², \> 34m/m2), FEVG \< 50% * ECG : QRS \> 90 ms * cardiac pathologies (excepted hypertension and valvulopathies) * History of stroke and transient ischemic attack * patient who didn't signed consent Group 3 * Inclusion Criteria : * cryptogenic stroke or transient ischemic attack history before 50 yo * No AF history * Exclusion Criteria : * AF history * stroke or transient ischemic attack over 50 yo * patient who didn't signed consent
Where this trial is running
Bourg-en-Bresse and 4 other locations
- Service neurologie Centre hospitalier Fleyriat — Bourg-en-Bresse, France (Recruiting)
- Service d'urgences Neurovasculaires - service de neurologie vasculaire , Hôpital Pierre Wertheimer — Bron, France (Recruiting)
- Service de rythmologie, hôpital cardiologique Louis Pradel — Bron, France (Recruiting)
- Service de médecine gériatrique Centre hospitalier Lyon Sud, Groupement hospitalier Sud — Pierre-Bénite, France (Recruiting)
- Hôpital des charpennes — Villeurbanne, France (Recruiting)
Study contacts
- Study coordinator: Philippe CHEVALIER, PU-PH
- Email: philippe.chevalier@chu-lyon.fr
- Phone: 04 72 35 70 27
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.