Biological and pathophysiological features linked to sexual orientation in men

Investigating the Pathophysiological Nature of Homosexuality Patients in Egypt, England, China, and Mexico: Multicenter Study.

Observational Tanta University · NCT05897177

This observational project will try to see whether certain biological markers and experiences of stigma differ in adult men who are gay compared with other men.

Quick facts

Study typeObservational
Enrollment500 (estimated)
Ages18 Years to 60 Years
SexMale
SponsorTanta University Academic / other
Locations1 site (Tanta)
Trial IDNCT05897177 on ClinicalTrials.gov

What this trial studies

This observational protocol enrolls adult men to collect clinical, biological, and self-report data, including the Subjective Scale of Stigma and Discrimination (SISD), to explore links between biological markers and male homosexual behavior. Eligibility excludes men taking testosterone or anabolic steroids, people with HIV, those reporting multi-sexual (bisexual) behavior, and individuals with addictive disorders. Data appear to be collected at a single site in Egypt (Tanta University) with no experimental treatments or interventions administered. The aim is to describe associations rather than to test a therapeutic intervention.

Who should consider this trial

Good fit: Ideal participants are men age 18 or older who are not taking testosterone or anabolic steroids, are HIV-negative, do not report multi-sexual behavior, and do not have an addictive disorder.

Not a fit: People under 18, women, men taking testosterone or anabolic steroids, people living with HIV, individuals reporting bisexual/multi-sexual behavior, or those with current addictive disorders are excluded and would not be expected to benefit from participation.

Why it matters

Potential benefit: If clear patterns are found, the work could help clarify biological contributors to male sexual orientation and inform clinical awareness and public discussion.

How similar studies have performed: Prior research has reported genetic, prenatal hormonal, and neuroanatomical associations with sexual orientation, but findings have been mixed and remain scientifically and socially controversial.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Age ≥ 18 years
* Male will be included

Exclusion Criteria:

* Patients taking testosterone or its derivative.
* Patients taking anabolic steroids.
* Multi-sexual behaviours.
* HIV patients.
* not having and addictive disorder

Where this trial is running

Tanta

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Psychiatric Disorder
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.