Biofortified eggs to boost vitamin D in healthy adults
Official title: Biofortified Vitamin D Metabolites in Eggs and Their Impact on Vitamin D Status and the Gut Microbiome
Run by Cornell University · NCT07859280 · Data updated 2026-11-12
Aiming to see if eating eggs enriched with vitamin D3 or its active form can raise vitamin D levels in healthy adults with low vitamin D.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 40 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Cornell University Academic / other |
| Locations | 1 site (Ithaca, New York) |
| Status | Recruiting |
| Started | January 2027 |
| Main results expected | July 2029 |
| Study ends | December 2029 |
| Registry record updated | October 5, 2026 |
| Trial ID | NCT07859280 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are healthy adults 18-40 years old with low vitamin D levels and no conditions or medications affecting vitamin D absorption.
✕Probably not a fit
Individuals with gastrointestinal disorders, recent antibiotic use, or conditions affecting vitamin D metabolism may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study tests whether consuming eggs bioenhanced with vitamin D3 or 25(OH)D3 for 8 weeks increases circulating vitamin D and 25(OH)D in young adults. It also explores whether differences in the gut microbiome relate to vitamin D status and whether the gut microbiome changes after supplementation. Participants are healthy, non-smoking adults aged 18-40, and the trial is conducted at Cornell’s Human Metabolic Research Unit.
Why it matters
Potential benefit: If successful, the approach could offer a dietary option to improve vitamin D status using everyday foods.
How similar studies have gone: Previous research suggests a link between vitamin D status and the gut microbiome, but the effects of bioenhanced food sources are still being explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy adults * Non-smoking * Age between 18- 40 years * Females: premenopausal and not pregnant or lactating * Body mass index (BMI) between 18.5-27.0 kg/m2. * No planned trip(s) to lower latitudes during the 8-week study Exclusion Criteria: * BMI \<18.5 or \> 27.0 kg/m2, * Age \<18 y or \> 40y, * Smoking * Pregnancy, lactating * Have gastrointestinal disorders/malabsorption diseases/dietary restrictions/use of medications known to impact vitamin D and 25(OH)D absorption * Been prescribed antibiotics within 3 months before enrolling * History or current diagnosis of any of the following conditions: intestinal problems (cystic fibrosis, Crohn's Disease, IBD, etc.), blood disorders (sickle cell, thalassemia, etc.), stomach problems (ulcers or other problems requiring antacids), joint diseases requiring anti-inflammatory medication, or asthma. * Planned trip(s) to lower latitudes during the 8-week study
Where it's running
-
Human Metabolic Research Unit
Ithaca, New York, United States Recruiting
Study contacts
- Study coordinator: Kimberly O'Brien, PhD
- Email: koo4@cornell.edu
- Phone: (607) 255-3743
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.