Biocidin liquid to reduce oral biofilms

Prospective Human Study Evaluating the Effects of Biocidin Liquid on Oral Biofilms: An Open-label Pilot Study

This will test whether two weeks of taking Biocidin liquid changes oral biofilms in healthy adults aged 25 and older.

Quick facts

• Phase: Not applicable
• Study type: Interventional
• Enrollment: 60 (estimated)
• Ages: 25 Years and up
• Sex: All
• Sponsor: OvationLab (Research network)
• Locations: 1 site (Richmond, Virginia)
• Trial ID: NCT07408245 on ClinicalTrials.gov

What this trial studies

This is a single-arm, open-label prospective trial in which participants take label dosing of Biocidin liquid for two weeks. Oral biofilm composition will be measured before and after the intervention using the SimplyPERIO oral microbiome test. Participants must maintain their usual oral hygiene and diet during the two-week period and be English-speaking adults aged 25 or older. Key exclusions include recent antibiotic use, current use of botanical mouthwashes, fixed orthodontic appliances, and pregnancy or lactation.

Who should consider this trial

Good fit: Ideal candidates are healthy English-speaking adults aged 25 or older who can follow a two-week Biocidin regimen, avoid changing oral care or diet, and complete SimplyPERIO testing before and after.

Not a fit: People currently using Biocidin or botanical mouthwashes, those who used antibiotics in the past 30 days, individuals with fixed orthodontic appliances, pregnant or lactating women, or those allergic to the product ingredients are unlikely to benefit or be eligible.

Why it matters

Potential benefit: If successful, Biocidin could reduce oral biofilm burden and potentially improve oral health markers such as gum inflammation or bacterial composition.

How similar studies have performed: Some small studies of botanical or antimicrobial mouthwashes have shown reductions in oral bacterial load, but clinical evidence specific to Biocidin and its effect on human oral biofilms is limited.

Eligibility criteria

Inclusion Criteria:

1. Adult females or males age ≥ 25 years
2. Ability to read and speak English
3. Willingness to take use oral Biocidin as directed for two weeks
4. Willingness not to change any other oral health practices for two weeks
5. Willingness not to change dietary habits for two weeks
6. Willingness to perform a SimplyPERIO oral microbiome test before and after the two-week Biocidin intervention

Exclusion Criteria:

1. Current use of oral Biocidin or botanical mouthwash
2. Use of antibiotics within the past 30 days
3. Current use of fixed intraoral orthodontic appliances (e.g., dental braces, fixed retainers, or similar devices)
4. Known allergies to any of the ingredients in the product
5. Currently pregnant or lactating women or women planning to become pregnant in the next 12 weeks
6. Participants unable to provide consent

Where this trial is running

Richmond, Virginia

• OvationLab — Richmond, Virginia, United States (Recruiting)

Study contacts

• Study coordinator: Chris D'Adamo, Ph.D.

Conditions Biofilm