Bioceramic versus resin-based root canal sealer and short-term pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized trial, 60 adults (ages 18–55) with non-vital teeth and radiographic periapical lesions (PAI 2–4) will receive root canal treatment using either a calcium-based bioceramic sealer or a resin-based sealer with single-cone Gutta-percha obturation. Standard cleaning, shaping, irrigation, and obturation procedures are used and patients are randomized to one of the two sealer groups. Postoperative pain is recorded on a 0–10 Numeric Pain Rating Scale at 4, 24, and 48 hours, and the highest reported score determines outcome categories (none, mild, moderate, severe). Patients with severe pain (8–10) are classified as treatment failures, and others as successes.

Why it matters

Who can join: the full rules

Inclusion Criteria:Age 18-55 years.

* Both genders.
* Teeth diagnosed with asymptomatic apical periodontitis.
* Teeth are asymptomatic (no pain on percussion or palpation).
* Non-vital pulp (no response on Electric Pulp Testing).
* Teeth with fully formed apices.
* Teeth with Periapical Index (PAI) scores 2-4 on radiographs.

Exclusion Criteria:

* Medically compromised patients (e.g., those with immunosuppressive or systemic diseases, or on medications that may affect healing).
* Patients who refuse to participate or are unable to communicate their symptoms (e.g., due to psychological disorders).
* Teeth where full working length cannot be reached.
* Periodontally compromised teeth (probing depth \>4 mm).
* Complications during treatment (e.g., separation of a file, ledging).
* Overfilling (filling beyond the radiographic apex) or short filling (\>2 mm from the radiographic apex).

Where it's running

• Fatima Memorial Hospital
  Lahore, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Shehryar Khan, Bachelor Of Dental SURGERY
• Email: shehryar_jadun@yahoo.com
• Phone: +92 336 9892535

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Cryotherapy after retreatment of a tooth: does cooling the canal reduce pain and inflammation?

  This trial tests whether intracanal cryotherapy with cold saline after endodontic retreatment reduces postoperative pain and inflammatory biomarkers in adults with a single-rooted mandibular premolar and asymptomatic apical periodontitis.

  Recruiting Alanya Alaaddin Keykubat University · Alanya, Antalya · NCT07733700

• Postoperative pain and short-term success after two root canal filling methods: cold lateral condensation versus warm vertical obturation

  This trial will test whether warm vertical obturation or cold lateral condensation causes less postoperative pain and better short-term healing in adults having root canal treatment for single-rooted necrotic teeth with asymptomatic apical periodontitis.

  Recruiting University of Jordan · Amman, Amman Governate · NCT07310212

• Comparing bio ceramic and epoxy resin sealers for pain after root canal treatment

  This study is testing whether using bio ceramic sealers or resin-based sealers during root canal treatment causes less pain for patients with a specific dental condition.

  Recruiting Primary Health Care Corporation, Qatar · Doha · NCT06543004

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.