Binge eating, depression, and anxiety after sleeve gastrectomy vs gastric bypass

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective cohort study compares two standard bariatric procedures—sleeve gastrectomy and gastric bypass—to see how they affect binge eating, mood, and anxiety over 12 months. It enrolls 100 adults aged 18–60 with BMI ≥35 (or ≥30 with a comorbidity) and follows them with validated Arabic questionnaires at multiple timepoints. Data will be analyzed to identify differences between procedures in binge eating, depression, anxiety, body image, and weight loss outcomes. All surgeries are performed under general anesthesia, and postoperative care follows a uniform diet and follow-up schedule. The choice of procedure is based on multidisciplinary evaluation and patient preference, reflecting real-world clinical practice.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 60 years
* Body Mass Index (BMI) ≥ 35 kg/m² without comorbidities, OR BMI ≥ 30 kg/m² with at least one obesity-related medical comorbidity (e.g., type 2 diabetes, hypertension, obstructive sleep apnea, dyslipidemia)
* Patient is generally fit for laparoscopic surgery and general anesthesia as determined by preoperative evaluation
* Patient agrees to comply with postoperative lifestyle changes (dietary modifications and follow-up schedule)
* Willing and able to provide written informed consent

Exclusion Criteria:

* Age \< 18 years or \> 60 years
* Inability or unwillingness to adhere to postoperative lifestyle changes
* Contraindication to surgery: American Society of Anesthesiologists (ASA) class IV or higher
* History of receiving radiotherapy or chemotherapy for cancer treatment
* Active substance use disorder or uncontrolled severe psychiatric illness that would impair ability to comply with study procedures (e.g., active psychosis, severe suicidal ideation)
* Pregnant or breastfeeding women (pregnancy test performed preoperatively per institutional protocol)
* Previous bariatric surgery (revisional surgery excluded)
* Untreated thyroid disorder (e.g., hypothyroidism or hyperthyroidism)

Where it's running

• Faculty of Medicine Cairo University
  Cairo, Al-Manial Cairo, Egypt Recruiting

Study contacts

• Study coordinator: Ahmed Eid Aziz, Lecturer
• Email: Ahmed-eid@kasralainy.edu.eg
• Phone: +201127060844

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.