Better to Exchange ETT for LMA Before Extubation in Children Under General Anaesthesia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial compares two end-of-anesthesia extubation strategies in pediatric patients: deep extubation with immediate LMA insertion followed by awake removal after PACU arrival, versus awake extubation from the endotracheal tube. It is conducted under real-world anesthesia practice with data collection in defined weekly blocks to ensure balanced representation. The study uses a waiver of informed consent and observes standard clinical care in participating institutions. Outcomes focus on airway safety and respiratory events during emergence from anesthesia. Eligible participants are children aged 0-16 years requiring endotracheal intubation for surgery, with key exclusions including severe cardiopulmonary disease or anticipated difficult airway.

Why it matters

Who can join: the full rules

Participant Inclusion Criteria

* Children 0-16 years,
* 5kg and above,
* presenting for elective, semi-elective or emergency surgery under general anaesthesia
* With airway management planned with an endotracheal tube.

Exclusion Criteria:

* Children with severe cardiopulmonary disease or syndrome
* Children \< 5kg
* Children with a contraindication to deep removal of ETT deep or exchange of ETT to LMA at the end of the case (e.g. high risk of aspiration)
* Children with a known or anticipated difficult airway
* Children remaining intubated post-procedure
* Children undergoing major airway surgery or bronchoscopies

Where it's running

• Perth Children's Hospital
  Nedlands, Western Australia, Australia Recruiting
• Uppsala University Hospital
  Uppsala, Sweden Recruiting
• Atrium Health Wake Forest Baptist
  Winston-Salem, North Carolina, United States Not yet recruiting
• The Children's Hospital of Philadelphia
  Philadelphia, Pennsylvania, United States Not yet recruiting
• The Kids Research Institute Australia
  Nedlands, Western Australia, Australia Active not recruiting
• University of São Paulo
  São Paulo, Brazil Not yet recruiting

Study contacts

• Study coordinator: Britta S. von Ungern-Sternberg, MD PHD
• Email: britta.regli-vonungern@health.wa.gov.au
• Phone: +618 6456 4806

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Hyperangulated vs. Macintosh blades for obstetric intubation

  This study tests whether a hyperangulated blade or a Macintosh-style blade helps obstetric patients get an endotracheal tube placement more safely during cesarean deliveries under general anesthesia.

  Recruiting Samuel Lunenfeld Research Institute, Mount Sinai Hospital · Toronto, Ontario · NCT07667010

• Infrared thermography to predict erector spinae plane block success in children having unilateral inguinal hernia repair

  This project will test whether temperature changes seen on a thermal camera can tell if an erector spinae plane block worked in children aged 3 months to 6 years having unilateral inguinal hernia repair under general anesthesia.

  Recruiting Cairo University · Cairo · NCT07161375

• Observing nutrition in critically ill children

  This study looks at how children in intensive care are fed to see if different nutrition methods can help them recover better and faster.

  Recruiting at 11 sites Australian and New Zealand Intensive Care Research Centre · Adelaide and 10 other locations · NCT06695078

• Using apnoeic oxygenation to improve pediatric tracheal intubation outcomes

  This study is testing if using extra oxygen during tracheal intubation can help improve outcomes for children having anesthesia.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT06576596

• Automated prediction of difficult intubation from face photos and short video

  This project will test an AI tool that uses face photos and short videos taken at pre‑anesthesia visits to predict whether adults having elective general anesthesia will be difficult to intubate with three common videolaryngoscopes.

  Recruiting Centre Hospitalier Universitaire Vaudois · Lausanne · NCT06453525

• Prospective review of airway management incidents in adult anesthesia care

  This project will record airway management for adults having anesthesia at several hospitals to see how often and what types of airway problems happen.

  Recruiting Insel Gruppe AG, University Hospital Bern · Berlin and 4 other locations · NCT06117176

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.