Beta-glucan added to a low-calorie, low-carbohydrate diet to help overweight women lose weight and body fat
Official title: Beta-glucan Supplementation During Calorie and Carbohydrate-restricted Diet: Impact on Body Weight and Body Fat Loss, Subjective Appetite, and Gastrointestinal Appetite Hormones of Healthy Women With Overweight.
Run by University of Glasgow · NCT07299942 · Data updated 2026-11-12
This trial will test whether taking 9 g/day of beta-glucan with a calorie- and carbohydrate-restricted diet helps women with overweight or obesity lose weight, reduce body fat, and feel less hungry.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | Women only |
| Enrollment | 60 (estimated) |
| Sponsor | University of Glasgow Academic / other |
| Locations | 1 site (Glasgow) |
| Status | Recruiting |
| Started | July 1, 2024 |
| Main results expected | January 31, 2025 |
| Study ends | December 30, 2025 |
| Registry record updated | December 23, 2025 |
| Trial ID | NCT07299942 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are sedentary women aged 18–60 with BMI 25–39.9 kg/m2, stable weight for ≥3 months, non-smokers, not pregnant or lactating, exercising ≤75 minutes/week, not following vegan/vegetarian diets, and not taking dietary supplements.
✕Probably not a fit
Men, people outside the age or BMI range, pregnant or lactating women, smokers, high exercisers, those on vegan/vegetarian diets, or people already taking supplements are unlikely to be eligible and therefore may not receive benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This double-blind, randomized, placebo-controlled trial will enroll about 60 sedentary women aged 18–60 with BMI 25–39.9 kg/m2 to compare 9 g/day beta-glucan versus 9 g/day cellulose over a 4-week calorie- and carbohydrate-restricted diet. Breakfasts and dinners will be energy-restricted meal replacements (200 kcal each) and lunches will be low-carbohydrate meals, with both groups following the same diet plan. Outcomes include body weight, body fat, subjective appetite measures, and gastrointestinal appetite hormones measured before and after the intervention. Randomization is 1:1 and study packs are labeled by an independent person to maintain blinding.
Why it matters
Potential benefit: If successful, adding beta-glucan could modestly increase short-term weight and body fat loss and help reduce hunger during calorie- and carbohydrate-restricted diets for women with overweight or obesity.
How similar studies have gone: Previous studies of soluble fibers like beta-glucan have shown modest benefits for satiety and metabolic markers, but using concentrated beta-glucan with a short-term calorie- and carbohydrate-restricted diet for body-fat loss is relatively under-studied.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Healthy females living with overweight or obese (BMI of 25 - 39.9 kg/m2). * Age between 18 to 60 years. * Stable body weight for at least 3 months preceding the study. Exclusion Criteria: * Smokers * Irregular menstrual cycle * Exercising more than 75min a week * Pregnant or lactating * Food allergies * Vegan or vegetarian or follow any diet other than the typical Western diet. * Taking dietary supplement at the time of the study.
Where it's running
-
Human Nutrition, College of Medicine, Veterinary and Life Science,
Glasgow, United Kingdom Recruiting
Study contacts
- Study coordinator: Dalia Malkova
- Email: Dalia.Malkova@glasgow.ac.uk
- Phone: 01412018690
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.