Behavioral treatments for quitting smoking
Neural Mechanisms Mediating Appetitive Regulation and Smoking in Nicotine Addiction
This study tests if two different therapies, one focused on mindfulness and the other on changing thought patterns, can help people who smoke quit for good.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | University of Missouri-Columbia Academic / other |
| Locations | 2 sites (Columbia, Missouri and 1 other locations) |
| Trial ID | NCT03948893 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effectiveness of two behavioral interventions, Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT), on smoking cessation. MORE integrates mindfulness training to alter reward processes associated with smoking, while CBT helps individuals understand the relationship between their thoughts, feelings, and smoking behaviors. Participants will be current nicotine-dependent smokers who are interested in quitting and will undergo these interventions to assess their impact on smoking behavior.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are current smokers with a minimum smoking history of 2 years and are interested in quitting.
Not a fit: Patients with untreated medical illnesses, current psychosis, or those on certain psychotropic medications may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide effective behavioral strategies to help individuals quit smoking.
How similar studies have performed: Other studies have shown success with behavioral interventions for smoking cessation, indicating that this approach is supported by existing evidence.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 and up * English fluency as demonstrated in providing informed consent and the ability to independently follow directions in completing assigned assessments and tasks * Functional vision (with corrective lenses as needed) to complete assigned assessments and tasks * Current nicotine dependent smoker with a minimum smoking history of 2 years * Interest in quitting smoking Exclusion Criteria: * Use of psychotropic (e.g. antiepileptic) medications in the past month * Positive urine drug screen * Presence of an untreated medical illness * Current or past psychosis * History of major neurological illness or head injury resulting in loss of consciousness * And contraindication to MRI, including claustrophobia * Among females, positive urine pregnancy test * Inability or unwillingness of subject to give informed consent
Where this trial is running
Columbia, Missouri and 1 other locations
- University of Missouri - Columbia — Columbia, Missouri, United States (Recruiting)
- Medical University of South Carolina — Charleston, South Carolina, United States (Not_yet_recruiting)
Study contacts
- Study coordinator: Madhura Athreya, MS
- Email: athreyam@health.missouri.edu
- Phone: 5738822977
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.