Behavioral program to improve heart health for people living with HIV

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The trial enrolls adults 40 and older living with HIV who are on antiretroviral therapy, virally suppressed, and classified as American Heart Association stage A or B heart failure but who are currently physically inactive. Participants receive a tailored exercise program, structured education sessions, behavioral coaching, and mobile health support to increase physical activity and promote guideline-recommended cardiovascular care. The intervention combines in-person and remote components designed to overcome barriers to exercise adherence and sustain lifestyle change. Investigators will track changes in physical activity, cardiovascular risk markers, and the feasibility and acceptability of the approach as a proof-of-concept.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Confirmed HIV infection (verified on medical record)
* Age ≥40 years
* Classified as heart failure stage A or B (American Heart Association Guidelines)
* On antiretroviral therapy (ART) for ≥12 months
* HIV RNA \<200 copies/mL in the past 12 months
* Not engaged in a structured exercise or weight loss program in the past 6 months
* Physically inactive, defined as an activity level of less than 400 METs measured with the Global Physical Activity Questionnaire (GPAQ)
* Independent in basic activities of daily living
* Able to ambulate independently

Exclusion Criteria:

* Heart failure stage C or D (AHA Guidelines)
* Participating in structured exercise or weight loss program in the past 6 months
* Exercising ≥3 times per week (≥20 minutes per session)
* Do not report fatigue
* Significant comorbidities (e.g., uncontrolled hypertension, severe musculoskeletal/neurological conditions)
* Pregnant or postmenopausal women

Where it's running

• University of Washington
  Seattle, Washington, United States Recruiting
• Londrina State University
  Londrina, Paraná, Brazil Recruiting

Study contacts

• Principal investigator: Vitor Oliveira, PhD — University of Washington
• Study coordinator: André Pereira dos Santos, PhD
• Email: andreps@uw.edu
• Phone: 206-380-3048

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.