Beet juice effects on heart and breathing muscles in older adults
Effect of Beet Juice Supplementation on Vascular and Inspiratory Muscle Function
This study tests whether drinking beet juice can help older adults with heart disease improve their heart and breathing muscle function.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 24 (estimated) |
| Ages | 60 Years to 85 Years |
| Sex | All |
| Sponsor | University of Florida Academic / other |
| Locations | 1 site (Gainesville, Florida) |
| Trial ID | NCT04920799 on ClinicalTrials.gov |
What this trial studies
This study investigates how beet juice supplementation affects vascular and inspiratory muscle function in older adults suffering from coronary artery disease (CAD). Participants aged 60 to 85 with stable CAD will receive either nitrate-rich beetroot juice or nitrate-depleted beetroot juice to assess improvements in their cardiovascular and respiratory health. The study aims to provide insights into the potential benefits of dietary nitrates for enhancing muscle function in this population.
Who should consider this trial
Good fit: Ideal candidates are adults aged 60 to 85 with stable coronary artery disease and a history of significant coronary artery blockage or myocardial infarction.
Not a fit: Patients with severe heart conditions, recent heart events, or other significant health issues may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to dietary interventions that improve heart and lung function in older adults with coronary artery disease.
How similar studies have performed: While the specific effects of beet juice on inspiratory muscle function are less explored, other studies have shown positive outcomes of dietary nitrates on cardiovascular health.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults with coronary artery disease (CAD) based on an angiogram \>50% stenosis in any major epicardial vessel or history of myocardial infarction or history of coronary revascularization. * Considered to have stable CAD on optimal medical therapy * 60 to 85 years of age * Men and women (women must be postmenopausal either natural or surgical) * Able to give consent Exclusion Criteria: * Ejection fraction \<50%, unstable angina, recent myocardial infarction within 6 months * Coronary revascularization, including percutaneous coronary intervention and coronary artery bypass graft or thoracic surgery within 6 months. * Stroke, obstructive pulmonary disease, hepatitis B, C, HIV, seizures, or other relevant on-going or recurrent illness * Individuals that have participated in respiratory training within the last 12 months or cardiac rehabilitation within the last 6 months * Uncontrolled hypertension * Use of tobacco products including smoking traditional or e-cigarettes * Use of hormone replacement therapy in women or men (e.g., estrogen, progesterone or testosterone) * Regular aerobic exercise training * Unwilling to stop using mouthwash at least 1 week before the start of the study and during study participation * Unwilling to remain weight stable during study participation
Where this trial is running
Gainesville, Florida
- Integrative Cardiovascular Physiology Laboratory, University of Florida — Gainesville, Florida, United States (Recruiting)
Study contacts
- Study coordinator: Demetra Christou, PhD
- Email: ddchristou@hhp.ufl.edu
- Phone: 352-294-1746
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.