Bedside heart ultrasound to predict successful removal of the breathing tube in ICU patients
Evaluation of Left Ventricular Function to Predict Weaning Success in the Intensive Care Unit: A Prospective Observational Study
This project will test whether bedside heart ultrasound measurements can predict successful extubation in adults on mechanical ventilation in the ICU.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 50 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Kanuni Sultan Suleyman Training and Research Hospital Academic / other |
| Locations | 1 site (Istanbul, Istanbul) |
| Trial ID | NCT07075926 on ClinicalTrials.gov |
What this trial studies
This is a prospective, single-center observational study enrolling adult ICU patients who meet standard weaning criteria. Participants will undergo transthoracic echocardiography within two hours of readiness for extubation to measure LVOT VTI, MAPSE, E/e', E/A, mitral deceleration time, and the Tei index. Patients will be monitored for 24 hours after extubation to determine weaning success, defined as maintaining spontaneous breathing without reintubation, noninvasive ventilation, or high-flow oxygen. The study aims to identify which left ventricular systolic, diastolic, and global function parameters best predict extubation outcomes to support physiologically guided weaning decisions.
Who should consider this trial
Good fit: Adults receiving mechanical ventilation in the ICU who are planned for extubation, hemodynamically stable, and able to undergo transthoracic echocardiography are ideal candidates.
Not a fit: Patients with significant valvular disease, known cardiomyopathy, inadequate acoustic windows, recent surgery within 24 hours, ongoing extracorporeal support, planned prophylactic re-intubation, or who are imminently dying are unlikely to benefit or are excluded.
Why it matters
Potential benefit: If successful, this approach could enable clinicians to use noninvasive bedside cardiac measurements to reduce extubation failure and related complications.
How similar studies have performed: Previous observational studies have reported that echocardiographic measures such as E/e' and LVOT VTI can be associated with weaning outcomes, but findings are variable and not yet definitive.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Currently receiving mechanical ventilation in the ICU * Planned extubation after meeting standard weaning criteria * Hemodynamically stable at the time of echocardiographic evaluation * Written informed consent obtained from the patient or legally authorized representative Exclusion Criteria: * Surgery within the previous 24 hours * Presence of significant valvular heart disease or known cardiomyopathy * Inadequate acoustic window for transthoracic echocardiography * Ongoing use of extracorporeal support (e.g., ECMO) * Patients with Do-Not-Resuscitate (DNR) orders or expected to die within 24 hours * Re-intubation planned prophylactically regardless of clinical status * Pregnant patients
Where this trial is running
Istanbul, Istanbul
- Health Science University İstanbul Kanuni Sultan Süleyman Education and Training Hospital — Istanbul, Istanbul, Turkey (Türkiye) (Recruiting)
Study contacts
- Study coordinator: Engin ihsan Turan, principal investigator
- Email: enginihsan@hotmail.com
- Phone: +905382431114
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.