Bariatric Surgery Combined With GLP-1RA in Obesity Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter study in China evaluates the real-world effectiveness of combining bariatric surgery with GLP-1RA therapy in adults with obesity and metabolic comorbidities. Participants undergo primary laparoscopic sleeve gastrectomy and are assigned to either the BS-GLP1RA group or the BS group. The study looks at weight change and metabolic outcomes across diverse regional cohorts to see if the combination offers added benefit beyond surgery alone. It excludes individuals with recent GLP-1RA exposure, prior bariatric surgery, or certain severe comorbidities. Outcomes will inform generalizability of this approach in a multi-regional, real-world setting.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Primary metabolic surgery candidates: Patients undergoing initial laparoscopic sleeve gastrectomy (LSG).
2. obesity:BMI ≥27.5 kg/m².
3. Metabolic comorbidities: Diagnosis of metabolic syndrome or type 2 diabetes mellitus (T2DM) meeting standard criteria.
4. Age range: 16-70 years (inclusive).
5. Informed consent: Willing participation with documented consent.

Exclusion Criteria:

1. Recent GLP-1RA use: Treatment with GLP-1 receptor agonists within 6 months preoperatively.
2. Prior bariatric surgery: History of any metabolic/bariatric surgical procedure.
3. Postoperative complications: Requiring reoperation for severe complications (e.g., hemorrhage, anastomotic leak).
4. Non-indicated candidates: Patients not meeting standard bariatric surgery indications.
5. Significant comorbidities:

Advanced hepatic/renal dysfunction (Child-Pugh C or eGFR \<30 mL/min/1.73m²) Active malignancy (except non-melanoma skin cancers) Autoimmune disorders requiring immunosuppression Uncontrolled psychiatric conditions (e.g., active psychosis, severe depression)

Where it's running

• Xingtai Ninth Hospital
  Xingtai, Hebei, China Recruiting
• Zhengzhou Central Hospita
  Zhengzhou, Henan, China Recruiting
• The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology
  Baotou, Inner Mongolia, China Recruiting
• The Second Hospital, Cheeloo College of Medicine, Shandong University
  Jinan, Shandong, China Recruiting
• Sinopharm Tongmei General Hospital
  Datong, Shanxi, China Recruiting
• The First People Hospital Of Yunnan Province
  Kunming, Yunnan, China Recruiting

Study contacts

• Study coordinator: Yishan Huang
• Email: bucmyishan@163.com
• Phone: 86+18810621201

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.