Bachmann bundle versus right atrial appendage pacing in sick sinus syndrome
Prospective Cohort Study of Bachmann Bundle Versus Right Atrial Appendage Pacing: Impact on Atrial Cardiomyopathy Evaluated by Echocardiographic Parameters and Clinical Outcome
This research tests whether pacing the Bachmann bundle instead of the right atrial appendage reduces atrial structural and functional damage in people with sick sinus syndrome who are getting a permanent pacemaker.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 19 Years and up |
| Sex | All |
| Sponsor | Samsung Medical Center Academic / other |
| Locations | 1 site (Seoul, Seoul) |
| Trial ID | NCT07360067 on ClinicalTrials.gov |
What this trial studies
This single-center prospective observational cohort will compare patients with sick sinus syndrome who receive Bachmann bundle pacing versus conventional right atrial appendage pacing during de novo permanent pacemaker or ICD implantation. Participants will undergo baseline and serial echocardiography including left atrial size and left atrial strain measurements, with clinical follow-up to capture arrhythmias and other outcomes. Investigators will compare progression of atrial cardiomyopathy by analyzing changes in structural and functional atrial parameters and clinical event rates between the two pacing-site groups. The goal is to see whether improved interatrial conduction with Bachmann bundle pacing leads to less atrial remodeling and better clinical outcomes over time.
Who should consider this trial
Good fit: Adults aged 19 years or older with sick sinus syndrome who are scheduled for de novo permanent pacemaker or implantable cardioverter-defibrillator implantation and who consent to study participation are eligible.
Not a fit: Patients with persistent or permanent atrial fibrillation, a life expectancy under one year, pregnant or breastfeeding women, or those who refuse active treatment are unlikely to benefit from this pacing comparison.
Why it matters
Potential benefit: If successful, this approach could preserve atrial structure and function and reduce atrial arrhythmias and related complications in paced patients.
How similar studies have performed: Prior research has reported reduced arrhythmia incidence with Bachmann bundle pacing, but effects on atrial structural and functional remodeling remain unproven.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 19 years or older * Patients diagnosed with sick sinus syndrome who are scheduled for de novo implantation of a permanent pacemaker or permanent implantable cardioverter-defibrillator * Patients or their legal representatives who voluntarily consent to the access of medical records and study data throughout the entire research period Exclusion Criteria: * Patients with persistent or permanent AF * Patients with a life expectancy of less than one year due to other comorbidities * Pregnant or breastfeeding women * Patients who refuse active treatment
Where this trial is running
Seoul, Seoul
- Samsung Medical Center — Seoul, Seoul, South Korea (Recruiting)
Study contacts
- Study coordinator: Kim Ju Won, Clinical assistant professor, Ph.D
- Email: abcd186a@naver.com
- Phone: 82+ 10-2079-8154
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.