Autonomic problems in Charcot–Marie–Tooth disease
Official title: AUTONOMOUS DISORDERS IN CMT
Run by University Medical Center Goettingen · NCT07570446 · Data updated 2026-11-12
This study will test how common and how severe autonomic (automatic nervous system) symptoms are in adults aged 18–65 with genetically confirmed Charcot–Marie–Tooth disease compared with healthy volunteers.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | University Medical Center Goettingen Academic / other |
| Locations | 1 site (Göttingen, Lower Saxony) |
| Status | Recruiting |
| Started | July 30, 2024 |
| Main results expected | July 5, 2026 |
| Study ends | July 30, 2026 |
| Registry record updated | May 6, 2026 |
| Trial ID | NCT07570446 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–65 with a clinical and genetic diagnosis of CMT who can give informed consent and complete baseline outcome measures, as well as consenting healthy control volunteers, are eligible.
✕Probably not a fit
Individuals outside the 18–65 age range, those who are pregnant or breastfeeding, or those with other relevant neurological, psychiatric, or serious internal diseases are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Participants with genetically confirmed CMT and an anamnestically healthy control group will complete symptom questionnaires and undergo non-invasive autonomic function tests to document presence and severity of autonomic dysfunction. Investigators will collect clinical data including genotype, disease duration, neurological impairment severity, and comorbidities. The study is observational and conducted at a single academic center, aiming to describe prevalence and characterize autonomic features rather than test an intervention. Data will be used to better define how autonomic symptoms contribute to daily functioning and quality of life in CMT patients.
Why it matters
Potential benefit: If successful, the findings could help clinicians recognize and manage autonomic symptoms in CMT patients, potentially improving daily functioning and quality of life.
How similar studies have gone: Previous smaller studies and case reports have reported autonomic symptoms in CMT, but comprehensive systematic data on prevalence and characteristics are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Clinical CMT Diagnosis / Anamnestically Healthy Control Group * Genetic confirmation of CMT in adult patients * Ability to achieve the outcome measure at baseline * Age between 18 and 65 years * Capacity of all study participants to consent and signed informed consent, - including patient or participant information and consent form Exclusion Criteria: * Pregnancy or breastfeeding period * Other relevant neurological or psychiatric disorders, acute or in the past history * Presence of a serious previous internal disease
Where it's running
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University Medical Centre
Göttingen, Lower Saxony, Germany Recruiting
Study contacts
- Study coordinator: Michael W Sereda, Prof. MD
- Email: sereda@mpinat.mpg.de
- Phone: +49 551 3964162
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.