Automating Total Marrow Irradiation for Hematological Diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project focuses on optimizing Total Marrow Irradiation (TMI) using advanced AI algorithms to enhance treatment for patients with hematological diseases. The study aims to reduce the time required for TMI planning from 10 days to a more efficient timeframe, thereby improving the overall treatment process for patients undergoing allogeneic stem cell transplantation. By utilizing whole-body CT and MRI imaging, the approach seeks to minimize radiation exposure to healthy tissues while maximizing the therapeutic dose to the bone marrow and lymphatic system. The goal is to improve patient outcomes and reduce toxicities associated with traditional Total Body Irradiation methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Written, signed informed consent
* Adult patients aged ≥18 years
* Diagnosis of Hematological disease
* Eligibility for allogeneic stem cell transplantation as center guidelines
* TMI/TLI as part of the conditioning regimen

Exclusion Criteria:

- Conditioning regimen including only chemotherapeutic agents

Where it's running

• IRCCS Humanitas Research Center
  Rozzano, Milano, Italy Recruiting

Study contacts

• Study coordinator: Pietro Mancosu, PhD
• Email: pietro.mancosu@humanitas.it
• Phone: +390282248529

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.