Automated MRI for liver imaging
Fully Automated High-Throughput Quantitative MRI of the Liver
This study is testing a new quick and easy MRI method for looking at the liver to see if it works better than regular MRIs for both healthy people and those with liver problems.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 7 Years and up |
| Sex | All |
| Sponsor | University of Wisconsin, Madison Academic / other |
| Locations | 1 site (Madison, Wisconsin) |
| Trial ID | NCT05294471 on ClinicalTrials.gov |
What this trial studies
This research aims to develop and test a new automated MRI method that allows for quick and efficient imaging of the liver. Participants, including healthy adults and those with known or suspected liver conditions, will undergo a single-button push MRI exam designed to minimize variability and improve image quality. The study will evaluate the method's repeatability, reproducibility, and technical success compared to traditional MRI techniques. The goal is to achieve a reliable, low-cost evaluation of chronic liver disease in under five minutes.
Who should consider this trial
Good fit: Ideal candidates include healthy adults and individuals aged 7 years or older with known or suspected liver iron overload or elevated liver fat.
Not a fit: Patients with contraindications to MRI, such as those with pacemakers or claustrophobia, will not benefit from this study.
Why it matters
Potential benefit: If successful, this method could provide faster and more accurate liver imaging, improving diagnosis and monitoring of liver diseases.
How similar studies have performed: While this approach is innovative, similar studies have shown promise in improving MRI techniques, suggesting potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Eligibility Criteria for Substudies 1, 2, 4, 5 Inclusion Criteria: * Age 18 years or older Exclusion Criteria: * Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc) * Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening) Eligibility Criteria for Substudy 3 Inclusion Criteria: * Age 7 years or older * One of: * Known or suspected liver iron overload * Known or suspected elevated liver fat Exclusion Criteria: * Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc) * Patients requiring intravenous (IV) conscious sedation for imaging are not eligible; patients requiring mild, oral anxiolytics for the MRI will be allowed to participate as long as the following criteria are met: * The subject has their own prescription for the medication. * The informed consent process is conducted prior to the self-administration of this medication * They come to the research visit with a driver * Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening) Eligibility Criteria for Substudy 6 Inclusion Criteria: * Age 7 years or older * Scheduled for a clinical abdominal MRI exam Exclusion Criteria: * Patients with contraindication to MRI (e.g. pacemaker, contraindicated metallic implants, claustrophobia, etc) * Sedation required for MRI * Pregnant or trying to become pregnant (as determined by self-report during MRI safety screening)
Where this trial is running
Madison, Wisconsin
- University of Wisconsin — Madison, Wisconsin, United States (Recruiting)
Study contacts
- Principal investigator: Scott Reeder, MD, PhD — University of Wisconsin, Madison
- Study coordinator: Radiology Studies
- Email: radstudy@uwhealth.org
- Phone: 608-282-8349
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.