Clinical trial Recruiting at 1 site Interventional Ages 20 and up Women only

Autologous TILs for Recurrent Ovarian Cancer

Official title: A Clinical Trial to Evaluate the Safety of Autologous Tumor-infiltrating Lymphocytes(TILs) for the Treatment of Recurrent Ovarian Cancer

Run by CHA University · NCT07651124 · Data updated 2026-11-12

A patient-focused study tests whether a patient’s own tumor-infiltrating lymphocytes can be safely given as a one-time infusion to see if it helps with recurrent ovarian cancer.

Quick facts

Study typeInterventional
Ages20 Years and up
SexWomen only
Enrollment6 (estimated)
SponsorCHA University
Academic / other
Drugs / interventionsimmunotherapy
Locations1 site (Gyeonggi-do, Bundang-gu)
StatusRecruiting
StartedApril 1, 2025
Main results expectedDecember 31, 2026
Study endsJune 30, 2027
Registry record updatedJune 16, 2026
Trial IDNCT07651124 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with recurrent ovarian cancer and at least one accessible tumor lesion suitable for biopsy or surgical removal.

Probably not a fit

Patients with immunodeficiency, autoimmune issues, or factors making them unsuitable for immunotherapy may not benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study collects tumor tissue from participants to grow enhanced autologous tumor-infiltrating lymphocytes (CHA-TIL) in the lab. The prepared cells are then given back to the patient through a single IV infusion to assess safety and any signs of benefit over 6 months. The trial focuses on safety first, with preliminary checks on efficacy in recurrent ovarian cancer. Eligible participants must have a biopsy- or surgery-accessible tumor and no immunodeficiency or autoimmune conditions that could worsen with immunotherapy.

Why it matters

Potential benefit: If successful, patients might experience disease control or symptom relief from the infused TILs.

How similar studies have gone: Preliminary studies in TIL-based therapies have shown safety signals and possible efficacy in some solid tumors, but results vary by cancer type.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Recurrent ovarian cancer
* There is a cancerous lesion that can be removed by biopsy or surgery.

Exclusion Criteria:

* Patient with immunodeficiency or autoimmune diseases that may be exacerbated by immunotherapy
* Patient deemed unsuitable by the principal investigator

Where it's running

  • Bundang CHA Medical Center
    Gyeonggi-do, Bundang-gu, South Korea
    Recruiting

Study contacts

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How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.