Autologous TILs for Recurrent Ovarian Cancer
Official title: A Clinical Trial to Evaluate the Safety of Autologous Tumor-infiltrating Lymphocytes(TILs) for the Treatment of Recurrent Ovarian Cancer
Run by CHA University · NCT07651124 · Data updated 2026-11-12
A patient-focused study tests whether a patient’s own tumor-infiltrating lymphocytes can be safely given as a one-time infusion to see if it helps with recurrent ovarian cancer.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years and up |
| Sex | Women only |
| Enrollment | 6 (estimated) |
| Sponsor | CHA University Academic / other |
| Drugs / interventions | immunotherapy |
| Locations | 1 site (Gyeonggi-do, Bundang-gu) |
| Status | Recruiting |
| Started | April 1, 2025 |
| Main results expected | December 31, 2026 |
| Study ends | June 30, 2027 |
| Registry record updated | June 16, 2026 |
| Trial ID | NCT07651124 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with recurrent ovarian cancer and at least one accessible tumor lesion suitable for biopsy or surgical removal.
✕Probably not a fit
Patients with immunodeficiency, autoimmune issues, or factors making them unsuitable for immunotherapy may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study collects tumor tissue from participants to grow enhanced autologous tumor-infiltrating lymphocytes (CHA-TIL) in the lab. The prepared cells are then given back to the patient through a single IV infusion to assess safety and any signs of benefit over 6 months. The trial focuses on safety first, with preliminary checks on efficacy in recurrent ovarian cancer. Eligible participants must have a biopsy- or surgery-accessible tumor and no immunodeficiency or autoimmune conditions that could worsen with immunotherapy.
Why it matters
Potential benefit: If successful, patients might experience disease control or symptom relief from the infused TILs.
How similar studies have gone: Preliminary studies in TIL-based therapies have shown safety signals and possible efficacy in some solid tumors, but results vary by cancer type.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Recurrent ovarian cancer * There is a cancerous lesion that can be removed by biopsy or surgery. Exclusion Criteria: * Patient with immunodeficiency or autoimmune diseases that may be exacerbated by immunotherapy * Patient deemed unsuitable by the principal investigator
Where it's running
-
Bundang CHA Medical Center
Gyeonggi-do, Bundang-gu, South Korea Recruiting
Study contacts
- Study coordinator: Yong Wha Moon
- Email: ymoon@cha.ac.kr
- Phone: 82-31-780-3436
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This study is testing a new combination of treatments for women with recurrent ovarian cancer to see if it can help them feel better and improve their outcomes.
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.