Assessment of chronic total occlusions using cardiac magnetic resonance
Chronic Total Occlusive Lesions CMR Study
This study is testing how well a non-invasive heart scan can help patients with blocked arteries understand their heart health before they undergo a procedure to improve blood flow.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 400 (estimated) |
| Ages | 18 Years to 80 Years |
| Sex | All |
| Sponsor | Beijing Anzhen Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT05614180 on ClinicalTrials.gov |
What this trial studies
This observational study will enroll patients with chronic total occlusions identified through coronary angiography who are scheduled for percutaneous coronary intervention. Participants will undergo a non-invasive cardiac magnetic resonance assessment to evaluate myocardial ischemia and viability before the procedure. Follow-up assessments will be conducted at three months and one year to measure changes in ischemia and angina severity using clinical evaluations and questionnaires. The primary goal is to determine the effectiveness of revascularization therapy in reducing ischemia and improving patient quality of life.
Who should consider this trial
Good fit: Ideal candidates are adults over 18 with at least one untreated chronic total occlusion and a clinical indication for percutaneous coronary intervention.
Not a fit: Patients with contraindications to cardiac magnetic resonance or severe chronic kidney disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies for patients with chronic total occlusions, enhancing their quality of life and reducing symptoms.
How similar studies have performed: Other studies have shown promising results using cardiac magnetic resonance for assessing myocardial ischemia, indicating potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Presence of at least one untreated CTO at basal angiography (defined as a total occlusion in any major coronary vessel or relevant side branches \[reference vessel diameter ≥2.5mm or as judged by two independent interventional cardiologists\], with TIMI 0 in the distal segment and at least 3 months old * Patient has a clinical indication to perform CTO PCI * Willing to participate and able to understand, read and sign the informed consent document. Exclusion Criteria: * CMR contraindications * Contraindications to adenosine or dobutamine * Severe chronic kidney disease (estimated Glomerular Filtration Rate \[eGFR\] \<60 mL/min/1.73m2 or serum creatinine level \>2.5 mg/dL)
Where this trial is running
Beijing, Beijing
- Beijing anzhen hospital — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Lin Zhao, MD — Beijing Anzhen Hospital
- Study coordinator: Xu Wang, MD
- Email: huaianwangxu@126.com
- Phone: +8615311765609
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.