Assessing whole-body metabolism in ovarian cancer patients
Dysregulation of Whole-body Metabolism in Ovarian Cancer: A Longitudinal Study
This study is testing how ovarian cancer affects fat metabolism in women before, during, and after their treatment to see if it can help find new ways to treat the disease.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 10 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | University of Tennessee Graduate School of Medicine Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Knoxville, Tennessee) |
| Trial ID | NCT06800105 on ClinicalTrials.gov |
What this trial studies
This observational study aims to investigate changes in whole-body lipid metabolism in women diagnosed with ovarian cancer. By utilizing indirect calorimetry, the study will measure fasting and postprandial lipid metabolism before, during, and after treatment, focusing on the metabolic profile of patients undergoing cytoreductive surgery followed by chemotherapy. The research seeks to identify potential metabolic targets for treatment by understanding how ovarian cancer affects lipid metabolism. This pilot study will also evaluate the feasibility and acceptability of the study protocol.
Who should consider this trial
Good fit: Ideal candidates are women over 18 with a presumed diagnosis of ovarian cancer who are planning to undergo cytoreductive surgery and chemotherapy.
Not a fit: Patients who are pregnant or have strict dietary restrictions that prevent them from consuming the study meal may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and potential new treatment targets for ovarian cancer patients.
How similar studies have performed: While there is limited information on similar studies specifically assessing whole-body lipid metabolism in ovarian cancer, the approach of studying metabolic changes in cancer patients has shown promise in other contexts.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women * Age \>18 * Presumed ovarian cancer diagnosis (i.e. those being clinically evaluated for suspicion of ovary cancer) * Planned treatment course for ovarian cancer involving cytoreductive surgery followed by chemotherapy * Availability to commit to attending all study visits * Internet access and consistent access to phone/email/text communication Exclusion Criteria: * Pregnancy * Inability to provide voluntary informed consent * Inability to consume the pre-study visit meal/snack and/or the study visit meal due to strict dietary restrictions * Illicit substance use (e.g. cocaine, methamphetamines, heroin, street drugs) - marijuana and CBD oil and related supplements will be considered on a case-by-case basis by the principal investigators * Circumstances and/or medical condition that would limit compliance with study requirements and protocol, as determined by the principal investigators
Where this trial is running
Knoxville, Tennessee
- University of Tennessee Graduate School of Medicine — Knoxville, Tennessee, United States (Recruiting)
Study contacts
- Study coordinator: Jill M Maples, PhD
- Email: jmaples1@utmck.edu
- Phone: 8653059367
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.