Assessing white matter changes in mild cognitive impairment and Alzheimer's disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to quantify and analyze white matter hyperintensities in the brains of individuals diagnosed with amnestic mild cognitive impairment (aMCI) or Alzheimer's disease. Using magnetic resonance imaging (MRI), the study will measure the extent and distribution of these hyperintensities, which are indicative of underlying cognitive disorders. The findings may help in understanding the neuropathological processes associated with these conditions and could serve as potential biomarkers for early diagnosis and prognosis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Participants diagnosed with amnestic Mild Cognitive Impairment (aMCI) or Alzheimer's Disease (AD) based on clinical assessments.
* Individuals undergoing brain magnetic resonance imaging (MRI) at the IRCCS Policlinico San Donato as part of routine diagnostic procedures.
* Age-matched and gender-matched healthy control subjects for comparison.

Exclusion Criteria:

* Individuals with cognitive impairment other than amnestic MCI or AD.
* History of significant neurological disorders (other than MCI or AD) that may impact the study outcomes.
* Presence of contraindications for undergoing MRI procedures.
* Any serious medical or psychiatric condition that, in the judgment of the researchers, may interfere with the study participation or compromise the validity of the results.
* Known history of alcohol or substance abuse that may affect cognitive function.
* Inability or unwillingness to provide informed consent.

Where it's running

• IRCCS Policlinico San Donato
  San Donato Milanese, Milano, Italy Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.