Assessing vascular inflammation in large vessel vasculitis using advanced imaging techniques
Official title: A Prospective, Observational Study on Prediction of Risk of Vascular Structural Damage in Patients With Large Vessel Vasculitis(LVV) Based on PET/MRA Image Evaluation System
Run by Nanjing Medical University · NCT06824714 · Data updated 2026-11-12
This study is testing advanced imaging techniques to see how well they can identify inflammation in the blood vessels of people with large vessel vasculitis to help guide their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Status | Recruiting |
| Started | January 1, 2024 |
| Main results expected | January 1, 2028 |
| Study ends | July 1, 2028 |
| Registry record updated | February 13, 2025 |
| Trial ID | NCT06824714 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals with clinically suspected or confirmed large vessel vasculitis who are willing to undergo PET/MRA imaging.
✕Probably not a fit
Patients with other serious cardiovascular or cerebrovascular diseases, severe mental disorders, or those who cannot undergo the required imaging due to medical devices or allergies may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate vascular wall inflammation in patients diagnosed with large vessel vasculitis (LVV) through the use of positron emission tomography and magnetic resonance imaging (PET/MRA). Participants will undergo a baseline clinical assessment, laboratory tests, and PET/MRA imaging, followed by a treatment protocol determined by clinicians. The study includes a 12-month follow-up period with clinic visits every 1-2 months for ongoing assessments and re-examinations. The goal is to improve the identification of vascular inflammation to guide treatment decisions effectively.
Why it matters
Potential benefit: If successful, this study could enhance the ability to detect vascular inflammation in LVV, leading to timely and more effective treatment options for patients.
How similar studies have gone: While this approach is innovative, similar studies utilizing advanced imaging techniques for vascular inflammation assessment have shown promise in other conditions.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Clinically suspected or confirmed LVV and willing to undergo PET/MRA 2. Compliance with long-term follow-up 3. Sign informed consent. Exclusion Criteria: 1. Patients with other serious cardiovascular and cerebrovascular diseases, malignant tumors, infectious diseases, severe renal insufficiency. 2. Severe mental disorders, severe claustrophobia unable to cooperate with the examination. 3. Patients equipped with cardiac pacemaker, artificial heart valve, ferromagnetic vascular clamp after vascular surgery, aneurysm clamp, artificial cochlea, insulin pump and other drug dosage control devices, steel nail plate and other metal internal fixation, artificial joint, electronic eye, artificial eye. 4. Allergic to contrast medium. 5. Pregnant or lactating women. Withdrawal criteria: 1. Any exclusion criteria emerged during patient follow-up. 2. Voluntarily withdrew from the study.
Where it's running
-
Department of Rheumatology and Immunology, Jiangsu Province Hospital, Nanjing Medical University
Nanjing, Jiangsu, China Recruiting
Study contacts
- Study coordinator: Rui LIU, MD
- Email: liurui_nanjing@163.com
- Phone: +86 15951871668
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Blocking endothelin to improve blood vessel function in large vessel vasculitis
This study is testing if a medication called Bosentan can improve blood vessel function in people with large vessel vasculitis who have been in remission for at least six months.
-
Undergraduate Nursing Interns: Do You Feel Connected to Your Future in Nursing?
This study follows nursing students during their clinical internship to see how their sense of belonging to the nursing role changes and what factors influence it.
-
Nudges to steer college students toward healthier beverage choices
Four groups of Chinese college students will try different nudges to see if it changes their choice between sugary and sugar-free drinks.
-
Using mild electrical brain stimulation plus DBT skills training for adults with ADHD
This trial will try adding mild electrical brain stimulation (tDCS) to DBT skills training to see if it helps adults with ADHD improve attention, impulse control, and daily functioning.
-
Dimethyl fumarate to preserve insulin-producing beta cells in adults with type 1 diabetes
This study will try adding dimethyl fumarate to insulin to see if it helps preserve beta-cell function in adults 18–65 with type 1 diabetes who still make some insulin.
-
Pre-ablation prehabilitation to improve recovery after atrial fibrillation ablation
A 4-week supervised program of exercise and psychological education will be tested in people with atrial fibrillation scheduled for their first catheter ablation to see if it improves post-procedure fitness and clinical outcomes compared with usual care.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.