Assessing vascular inflammation in large vessel vasculitis using advanced imaging techniques
A Prospective, Observational Study on Prediction of Risk of Vascular Structural Damage in Patients With Large Vessel Vasculitis(LVV) Based on PET/MRA Image Evaluation System
This study is testing advanced imaging techniques to see how well they can identify inflammation in the blood vessels of people with large vessel vasculitis to help guide their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Nanjing Medical University Academic / other |
| Locations | 1 site (Nanjing, Jiangsu) |
| Trial ID | NCT06824714 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate vascular wall inflammation in patients diagnosed with large vessel vasculitis (LVV) through the use of positron emission tomography and magnetic resonance imaging (PET/MRA). Participants will undergo a baseline clinical assessment, laboratory tests, and PET/MRA imaging, followed by a treatment protocol determined by clinicians. The study includes a 12-month follow-up period with clinic visits every 1-2 months for ongoing assessments and re-examinations. The goal is to improve the identification of vascular inflammation to guide treatment decisions effectively.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals with clinically suspected or confirmed large vessel vasculitis who are willing to undergo PET/MRA imaging.
Not a fit: Patients with other serious cardiovascular or cerebrovascular diseases, severe mental disorders, or those who cannot undergo the required imaging due to medical devices or allergies may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance the ability to detect vascular inflammation in LVV, leading to timely and more effective treatment options for patients.
How similar studies have performed: While this approach is innovative, similar studies utilizing advanced imaging techniques for vascular inflammation assessment have shown promise in other conditions.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Clinically suspected or confirmed LVV and willing to undergo PET/MRA 2. Compliance with long-term follow-up 3. Sign informed consent. Exclusion Criteria: 1. Patients with other serious cardiovascular and cerebrovascular diseases, malignant tumors, infectious diseases, severe renal insufficiency. 2. Severe mental disorders, severe claustrophobia unable to cooperate with the examination. 3. Patients equipped with cardiac pacemaker, artificial heart valve, ferromagnetic vascular clamp after vascular surgery, aneurysm clamp, artificial cochlea, insulin pump and other drug dosage control devices, steel nail plate and other metal internal fixation, artificial joint, electronic eye, artificial eye. 4. Allergic to contrast medium. 5. Pregnant or lactating women. Withdrawal criteria: 1. Any exclusion criteria emerged during patient follow-up. 2. Voluntarily withdrew from the study.
Where this trial is running
Nanjing, Jiangsu
- Department of Rheumatology and Immunology, Jiangsu Province Hospital, Nanjing Medical University — Nanjing, Jiangsu, China (Recruiting)
Study contacts
- Study coordinator: Rui LIU, MD
- Email: liurui_nanjing@163.com
- Phone: +86 15951871668
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.