Assessing Vagus Nerve Changes in Patients with Parkinsonism
Ultrasound Changes of the Vagus Nerve in Patients With Parkinsonism
This study is testing how the Vagus nerve differs in people with parkinsonism compared to healthy individuals to better understand its role in the condition.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 102 (estimated) |
| Sex | All |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Assiut) |
| Trial ID | NCT05834634 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the Vagus nerve in patients diagnosed with parkinsonism compared to healthy controls matched by age and sex. The researchers will utilize ultrasound technology to measure the cross-sectional area of the Vagus nerve and correlate these findings with both motor and non-motor symptoms associated with parkinsonism. By identifying differences between the two groups, the study seeks to enhance understanding of the Vagus nerve's role in this condition. The findings may provide insights into the pathophysiology of parkinsonism and its manifestations.
Who should consider this trial
Good fit: Ideal candidates include individuals diagnosed with parkinsonism who are willing to participate and provide informed consent.
Not a fit: Patients with chronic psychiatric conditions, other neurodegenerative disorders, or those who have undergone surgery near the Vagus nerve may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for patients with parkinsonism.
How similar studies have performed: While there is ongoing research into the role of the Vagus nerve in neurodegenerative diseases, this specific approach using ultrasound in parkinsonism is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
A) Inclusion Criteria: * All patients fulfill the criteria of case definition of parkinsonism. * Gender: both sexes are included. * Willingness to participate in the study and to be subjected to the disease-related examinations and assessments. * Willing and able to provide informed consent. B) Exclusion Criteria: * Patients unable to give informed consent. * History of chronic psychiatric or other central nervous system pathology and other neurodegenerative disorder(s). * Patients with previous surgery in proximity of the Vagus nerve (for example carotid endarterectomy or implantation of Vagus nerve stimulator). * Patients with known systemic diseases (such as diabetes mellitus, vascular disease, and peripheral neuropathy).
Where this trial is running
Assiut
- Assiut University — Assiut, Egypt (Recruiting)
Study contacts
- Principal investigator: Mohamed AR Ahmed — Assiut University
- Study coordinator: Ahmed M Abdeltawab
- Email: ahmad.mo.abdultawab996@gmail.com
- Phone: 01092346044
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.