Assessing the impact and cost-effectiveness of long-acting PrEP for HIV prevention
Official title: Epidemiological Impact and Cost-effectiveness of Long-acting Antiretrovirals for Pre-exposure Prophylaxis Among Key Populations in Thailand
Run by Institute of HIV Research and Innovation Foundation, Thailand · NCT05774548 · Data updated 2026-11-12
This study is testing how well long-acting PrEP works for preventing HIV and whether it's worth the cost by talking to HIV-negative men who have sex with men and transgender women about their preferences.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | Men only |
| Enrollment | 10720 (estimated) |
| Sponsor | Institute of HIV Research and Innovation Foundation, Thailand Academic / other |
| Locations | 12 sites (Bangkok, Bangkapi and 11 other locations) |
| Status | Recruiting |
| Started | March 15, 2022 |
| Main results expected | December 15, 2026 |
| Study ends | December 30, 2028 |
| Registry record updated | March 18, 2026 |
| Trial ID | NCT05774548 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are HIV-negative MSM and TGW aged 18 and older who have shown interest in, currently use, or have previously used PrEP.
✕Probably not a fit
Patients who are not willing to participate in the study or do not meet the eligibility criteria will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the impact and cost-effectiveness of long-acting PrEP through discrete choice experiments and analysis of routine service data. It involves conducting in-depth interviews and focus group discussions with HIV-negative men who have sex with men (MSM) and transgender women (TGW) to identify key attributes influencing PrEP use. The findings will inform mathematical modeling to assess user preferences and the overall effectiveness of PrEP strategies. The study aims to provide insights that can enhance PrEP uptake and optimize resource allocation in HIV prevention.
Why it matters
Potential benefit: If successful, this study could lead to improved strategies for increasing PrEP uptake among at-risk populations, ultimately reducing HIV transmission rates.
How similar studies have gone: Other studies have successfully utilized discrete choice experiments to inform healthcare decision-making, indicating that this approach is both valid and potentially impactful.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Minimum age of 18 years * Individual assigned male at birth reporting sex with men in the past 12 months * Self-reported HIV-negative MSM and TGW who either report interest in PrEP use, current PrEP use, or past PrEP use * Permit audio recording during the interview and/or discussion. Exclusion Criteria: * Not willing to participate in the study
Where it's running
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Rainbow Sky Association of Thailand (RSAT)
Bangkok, Bangkapi, Thailand Recruiting -
The Service Workers In Group Foundation (SWING)
Bangkok, Building 3, Patpong, Surawong Road, Thailand Recruiting -
The Service Workers In Group Foundation (SWING)
Bang Lamung, Changwat Chon Buri, Thailand Recruiting -
Rainbow Sky Association of Thailand (RSAT)
Chon Buri, Changwat Chon Buri, Thailand Recruiting -
Rainbow Sky Association of Thailand (RSAT)
Hat Yai, Changwat Songkhla, Thailand Recruiting -
Tangerine Clinic
Bangkok, Pathumwan, Thailand Recruiting
Show 6 more locations
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The Service Workers In Group Foundation (SWING)
Bangkok, Phay Thai, Thailand Recruiting -
Caremat
Chiang Mai, Thailand Recruiting -
Mplus Foundation
Chiang Mai, Thailand Recruiting -
Mplus Foundation
Chiang Rai, Thailand Recruiting -
Mplus Foundation
Phitsanulok, Thailand Recruiting -
Rainbow Sky Association of Thailand (RSAT)
Ubon Ratchathani, Thailand Recruiting
Study contacts
- Principal investigator: Nittaya Phanuphak, MD,PhD. — Institute of HIV Research and Innovation Foundation
- Study coordinator: Nittaya Phanuphak, MD,PhD.
- Email: nittaya.p@ihri.org
- Phone: 6681 825 3544
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.