Clinical trial Recruiting at 12 sites Interventional Ages 18 and up Men only

Assessing the impact and cost-effectiveness of long-acting PrEP for HIV prevention

Official title: Epidemiological Impact and Cost-effectiveness of Long-acting Antiretrovirals for Pre-exposure Prophylaxis Among Key Populations in Thailand

Run by Institute of HIV Research and Innovation Foundation, Thailand · NCT05774548 · Data updated 2026-11-12

This study is testing how well long-acting PrEP works for preventing HIV and whether it's worth the cost by talking to HIV-negative men who have sex with men and transgender women about their preferences.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexMen only
Enrollment10720 (estimated)
SponsorInstitute of HIV Research and Innovation Foundation, Thailand
Academic / other
Locations12 sites (Bangkok, Bangkapi and 11 other locations)
StatusRecruiting
StartedMarch 15, 2022
Main results expectedDecember 15, 2026
Study endsDecember 30, 2028
Registry record updatedMarch 18, 2026
Trial IDNCT05774548 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are HIV-negative MSM and TGW aged 18 and older who have shown interest in, currently use, or have previously used PrEP.

Probably not a fit

Patients who are not willing to participate in the study or do not meet the eligibility criteria will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the impact and cost-effectiveness of long-acting PrEP through discrete choice experiments and analysis of routine service data. It involves conducting in-depth interviews and focus group discussions with HIV-negative men who have sex with men (MSM) and transgender women (TGW) to identify key attributes influencing PrEP use. The findings will inform mathematical modeling to assess user preferences and the overall effectiveness of PrEP strategies. The study aims to provide insights that can enhance PrEP uptake and optimize resource allocation in HIV prevention.

Why it matters

Potential benefit: If successful, this study could lead to improved strategies for increasing PrEP uptake among at-risk populations, ultimately reducing HIV transmission rates.

How similar studies have gone: Other studies have successfully utilized discrete choice experiments to inform healthcare decision-making, indicating that this approach is both valid and potentially impactful.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Minimum age of 18 years
* Individual assigned male at birth reporting sex with men in the past 12 months
* Self-reported HIV-negative MSM and TGW who either report interest in PrEP use, current PrEP use, or past PrEP use
* Permit audio recording during the interview and/or discussion.

Exclusion Criteria:

* Not willing to participate in the study

Where it's running

  • Rainbow Sky Association of Thailand (RSAT)
    Bangkok, Bangkapi, Thailand
    Recruiting
  • The Service Workers In Group Foundation (SWING)
    Bangkok, Building 3, Patpong, Surawong Road, Thailand
    Recruiting
  • The Service Workers In Group Foundation (SWING)
    Bang Lamung, Changwat Chon Buri, Thailand
    Recruiting
  • Rainbow Sky Association of Thailand (RSAT)
    Chon Buri, Changwat Chon Buri, Thailand
    Recruiting
  • Rainbow Sky Association of Thailand (RSAT)
    Hat Yai, Changwat Songkhla, Thailand
    Recruiting
  • Tangerine Clinic
    Bangkok, Pathumwan, Thailand
    Recruiting
Show 6 more locations
  • The Service Workers In Group Foundation (SWING)
    Bangkok, Phay Thai, Thailand
    Recruiting
  • Caremat
    Chiang Mai, Thailand
    Recruiting
  • Mplus Foundation
    Chiang Mai, Thailand
    Recruiting
  • Mplus Foundation
    Chiang Rai, Thailand
    Recruiting
  • Mplus Foundation
    Phitsanulok, Thailand
    Recruiting
  • Rainbow Sky Association of Thailand (RSAT)
    Ubon Ratchathani, Thailand
    Recruiting

Study contacts

  • Principal investigator: Nittaya Phanuphak, MD,PhD. — Institute of HIV Research and Innovation Foundation
  • Study coordinator: Nittaya Phanuphak, MD,PhD.
  • Email: nittaya.p@ihri.org
  • Phone: 6681 825 3544

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.