Assessing testicular function and semen quality in young male cancer survivors
Effect of Cancer Treatment on Testicular Function and Semen Quality in Male Childhood and Adolescent Cancer Survivors
The University of Hong Kong · NCT06587477
This study is trying to see how well the testicles are working and the quality of semen in young men who survived cancer as kids or teens, compared to men their age who didn't have cancer.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 50 Years |
| Sex | Male |
| Sponsor | The University of Hong Kong (other) |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Hong Kong) |
| Trial ID | NCT06587477 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the testicular function and semen quality in male survivors of childhood and adolescent cancer who are now adults. Participants will include men aged 18 to 50 who received chemotherapy or radiotherapy for cancer diagnosed before age 18 and have been in remission for at least two years. The study will compare their testicular function with that of age-matched controls from a premarital check-up clinic. Data will be collected through hormonal profiling, semen analysis, and questionnaires.
Who should consider this trial
Good fit: Ideal candidates are men aged 18 to 50 who received cancer treatment before age 18 and have been in remission for at least two years.
Not a fit: Patients who are unable to provide semen samples or have specific medical conditions such as testicular cancer or are on testosterone replacement therapy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide critical insights for improving pre-treatment counseling and post-treatment care for young male cancer survivors.
How similar studies have performed: Other studies have shown success in assessing long-term effects of cancer treatment on reproductive health, making this approach both relevant and necessary.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Men who have received chemotherapy and/ or radiotherapy for cancer diagnosed when they were \< 18 years old. * \> 18 years old to 50 years old * Cancer in remission for at least 2 years Exclusion Criteria: * Unable to ejaculate by masturbation to provide semen samples * Cryptorchidism, testicular cancer, history of vasectomy * On testosterone replacement therapy * Refusal to join the study
Where this trial is running
Hong Kong
- Queen Mary Hospital — Hong Kong, China (RECRUITING)
Study contacts
- Study coordinator: Jennifer Ko
- Email: jenko@hku.hk
- Phone: 22554647
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Cancer, Treatment-Related, Late Effect, Semen Analysis, cancer treatment, testicular function, semen quality, cancer survivors