Assessing risks in patients without a spleen in France
Official title: Assessment of Complication Risk Factors in a French National Cohort of Asplenic Patients
Run by Poitiers University Hospital · NCT04199403 · Data updated 2026-11-12
This study looks at patients without a spleen to see what health risks they face and how to better manage their care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 6000 (estimated) |
| Sponsor | Poitiers University Hospital Academic / other |
| Locations | 12 sites (Angoulême and 11 other locations) |
| Status | Recruiting |
| Started | January 9, 2020 |
| Main results expected | January 2040 |
| Study ends | January 2040 |
| Registry record updated | July 16, 2026 |
| Trial ID | NCT04199403 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who are asplenic due to splenectomy, splenic artery embolization, or radiotherapy.
✕Probably not a fit
Patients with genetic asplenia, such as those with sickle cell disease, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on patients who have undergone splenectomy, splenic artery embolization, or radiotherapy leading to asplenia. It aims to assess the complications associated with asplenia, including infectious diseases, cancer, and thromboembolic events. The study will implement new diagnostic tools to better understand splenic function and immunity over time in these patients. By following a national cohort of asplenic patients, the research seeks to identify risk factors and improve management strategies for this vulnerable population.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic tools and management strategies for patients without a spleen, potentially reducing their risk of serious complications.
How similar studies have gone: While there have been studies on splenectomized patients, this approach of assessing complications in a national cohort with a focus on new diagnostic tools is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * ≥18 year-old * With asplenia due to splenectomy, splenic artery embolization or radiotherapy Exclusion Criteria: * Genetic asplenia including sick cell disease
Where it's running
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C.H. d'Angoulême
Angoulême, France Recruiting -
C.H. Victor Dupouy
Argenteuil, France Recruiting -
C.H.U. de Lille
Lille, France Recruiting -
C.H.U. de Montpellier
Montpellier, France Recruiting -
Hôtel-Dieu - CHU de Nantes
Nantes, France Recruiting -
C.H.U. de Poitiers
Poitiers, France Recruiting
Show 6 more locations
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C.H.U. de Toulouse
Toulouse, France Recruiting -
C.H. de Tourcoing
Tourcoing, France Recruiting -
C.H. de Valenciennes
Valenciennes, France Recruiting -
C.H. de Béthune
Béthune, France Withdrawn -
Hôpitaux de Chartres
Chartres, France Active not recruiting -
C.H.U. de Rouen
Rouen, France Not yet recruiting
Study contacts
- Principal investigator: Mathieu PUYADE, MD — C.H.U. de Poitiers
- Study coordinator: Mathieu PUYADE, MD
- Email: mathieu.puyade@chu-poitiers.fr
- Phone: +33 5 49 44 32 76
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Italian questionnaire to measure knowledge and vaccination attitudes in people without a spleen
This project will test a new Italian questionnaire to measure how much people without a spleen know about infection prevention and vaccination.
-
Education to prevent infections after spleen removal
See if a targeted educational program for adults who had their spleen removed improves vaccination uptake, awareness of infection risk, and continuity of care.
-
Investigating vaccine response in patients with spleen injuries
This study is testing how well a pneumonia vaccine works in adults with spleen injuries who are treated in different ways to see if their treatment affects their immune response.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.