Assessing risk factors and outcomes in patients with coronary chronic total occlusion
Risk Factors and Outcomes in Patients With Stable Coronary Artery Disease and Coronary Chronic Total Occlusion
Ruijin Hospital · NCT06137521
This study looks at how different treatments for coronary chronic total occlusion affect the long-term health of patients and what factors might influence their recovery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 3000 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ruijin Hospital (other) |
| Locations | 1 site (Shanghai) |
| Trial ID | NCT06137521 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the risk factors and long-term outcomes of patients suffering from coronary chronic total occlusion (CTO) who are treated either with percutaneous coronary intervention or medical management. It focuses on understanding how various baseline characteristics and treatment modalities influence the prognosis of CTO patients, who typically face worse outcomes compared to those without CTO. The study will involve collecting clinical data and blood samples to identify factors that may contribute to the development of coronary collateral formation and overall patient outcomes. Conducted at a single center, this research seeks to enhance clinical decision-making for managing coronary artery disease.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older with documented ischemia and chronic total occlusion lasting more than three months.
Not a fit: Patients with severe chronic heart failure, recent coronary interventions, or significant comorbidities such as malignancies or immune disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved treatment strategies and better outcomes for patients with coronary chronic total occlusion.
How similar studies have performed: While there have been studies on coronary artery disease, this specific focus on chronic total occlusion and its risk factors is relatively novel and not extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years; Patients with angina or silent ischemia and documented ischemia; Patients with CTO ≥ 3months Exclusion Criteria: * eGFR\<15mL/(min·1.73m2); Chronic heart failure with NYHA grade ≥3; Had a history of coronary artery bypass grafting; Had received a percutaneous coronary intervention within the prior 3 months; Malignant tumor or immune system disorders; Pulmonary heart disease
Where this trial is running
Shanghai
- Ruijin Hospital, Shanghai Jiao Tong University School of Medicine — Shanghai, China (RECRUITING)
Study contacts
- Study coordinator: Fenghua Ding, PhD, MD
- Email: ruijindfh@126.com
- Phone: 0086 021 64370045
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Chronic Total Occlusion, Coronary Artery Disease