Assessing respiratory muscle function after neurosurgery
The Development of Post-operative Respiratory Muscle Dysfunction in Neurosurgical Patients
This study is testing how well the breathing muscles work in patients after brain surgery to see if problems with these muscles are linked to breathing issues afterward.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Beijing Sanbo Brain Hospital Academic / other |
| Locations | 1 site (Beijing, Beijing) |
| Trial ID | NCT05951114 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate respiratory muscle dysfunction in patients undergoing neurosurgery and its correlation with postoperative pulmonary complications. Using ultrasound, the study will measure the function of the diaphragm and expiratory muscles in real-time. The primary goal is to determine the prevalence of respiratory muscle dysfunction in this patient population, while secondary aims include exploring the relationship between brain injury and respiratory muscle function, as well as the impact of dysfunction on pulmonary complications. The findings could provide valuable insights into improving postoperative care for neurosurgery patients.
Who should consider this trial
Good fit: Ideal candidates for this study are patients undergoing their first elective neurosurgical operation with an ASA score of 3 or lower.
Not a fit: Patients with brain stem or spinal lesions, those requiring mechanical ventilation before surgery, or individuals with a history of neuromuscular disease may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to better management strategies for preventing postoperative pulmonary complications in neurosurgery patients.
How similar studies have performed: While the specific approach of this study may be novel, previous studies have shown the feasibility of using ultrasound to assess respiratory muscle function in various surgical populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Informed consent * First elective operation during hospitalization * ASA\<3 Exclusion Criteria: * Brain stem and spinal spine lesions * Preoperative chest imaging findings were abnormal * Mechanical ventilation was required before surgery * Clinical or radiological evidence of preoperative misaspiration * History of neurosurgery in the last 6 months * A history of neuromuscular disease * BMI≥35kg/m2 * Pregnant women * Skin lesions detected by ultrasound
Where this trial is running
Beijing, Beijing
- Beijing Sanbo Brain Hospital, Capital Medical University — Beijing, Beijing, China (Recruiting)
Study contacts
- Principal investigator: Zhonghua Shi, PhD — Capital Medical University
- Study coordinator: Zhonghua Shi, PhD
- Email: z.shi@mail.ccmu.edu.cn
- Phone: 62856764
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.