Assessing quick tests for action slowing in stroke and cognitive diseases
Diagnostic and Prognostic Value of New Quick Tests of Action Slowing in Stroke and in Cognitive Neurodegenerative Disease
This study is testing new quick tests to see if they can help doctors understand how action slowing in stroke and cognitive disease patients can predict their recovery and diagnose conditions like Alzheimer's earlier.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 129 (estimated) |
| Ages | 40 Years to 85 Years |
| Sex | All |
| Sponsor | Centre Hospitalier Universitaire, Amiens Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Amiens) |
| Trial ID | NCT05785156 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the diagnostic and prognostic value of new quick tests that measure action slowing in patients with acute stroke and various cognitive neurodegenerative disorders, including Alzheimer's disease and related conditions. The study will investigate how action slowing can predict functional outcomes in stroke patients and its relevance in diagnosing early stages of neurodegenerative diseases. By analyzing the anatomical determinants of action slowing, the research seeks to enhance understanding of these conditions and improve diagnostic methods.
Who should consider this trial
Good fit: Ideal candidates for this study are French-speaking patients aged 40 to 85 with mild to major cognitive disorders related to Alzheimer's disease or other specified neurodegenerative conditions.
Not a fit: Patients with a history of severe brain conditions, previous dementia diagnoses, or significant psychiatric disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic tools and prognostic assessments for patients with stroke and cognitive neurodegenerative diseases.
How similar studies have performed: While there is ongoing research into action slowing in brain diseases, this specific approach using new quick tests is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients between 40 and 85 years old, * French native language, * Social Security affiliation. * University Memory Clinic for: Mild severity disorder (MMSE\> 19) or major severity disorder related to AD : Albert 2011 criteria ; McKhann 2011 * to MCL according to McKeith criteria * to FTLD according to Rascovsky 2011 criteria * BBD according to Armstrong's criteria * related to PSP according to Höglinger criteria Exclusion Criteria: * Mental retardation or guardianship * Previously diagnosed dementia * Other current or past brain condition * severe head trauma * epilepsy prior to stroke still requiring previous treatment * Parkinson disease, multiple sclerosis... * brain tumor or brain radiation therapy * Current or past schizophrenia or psychosis * Active or past psychiatric disorders requiring a stay\> 2 days in a specialized environment * Contra indication to MRI * Comorbidity with life expectancy \<1 year * Comorbidity affecting cognition in particular: * Alcohol (\> 3 glasses / day) or history of alcohol withdrawal syndrome * opiate or cocaine addiction or opiate withdrawal syndrome * renal failure (dialysis or creatinine clearance \<30) * hepatic failure (spontaneous INR\> 1.5 or PT \<60%) * respiratory failure requiring oxygen therapy * heart failure (orthopnea\> 2 pillows) * persistent vigilance disturbances (NIHSS1a score ≤1) * cancer with paraneoplastic syndrome * treatment with gold salts, D Penicillamine or other treatment with cognitive effect * Patient under guardianship or curators or private under public law * Pregnant and / or lactating wom
Where this trial is running
Amiens
- CHU Amiens — Amiens, France (Recruiting)
Study contacts
- Study coordinator: Martine ROUSSEL, PhD
- Email: roussel.martine@chu-amiens.fr
- Phone: 0322667813
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.