Assessing quick tests for action slowing in stroke and cognitive diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the diagnostic and prognostic value of new quick tests that measure action slowing in patients with acute stroke and various cognitive neurodegenerative disorders, including Alzheimer's disease and related conditions. The study will investigate how action slowing can predict functional outcomes in stroke patients and its relevance in diagnosing early stages of neurodegenerative diseases. By analyzing the anatomical determinants of action slowing, the research seeks to enhance understanding of these conditions and improve diagnostic methods.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients between 40 and 85 years old,
* French native language,
* Social Security affiliation.
* University Memory Clinic for: Mild severity disorder (MMSE\> 19) or major severity disorder related to AD : Albert 2011 criteria ; McKhann 2011
* to MCL according to McKeith criteria
* to FTLD according to Rascovsky 2011 criteria
* BBD according to Armstrong's criteria
* related to PSP according to Höglinger criteria

Exclusion Criteria:

* Mental retardation or guardianship
* Previously diagnosed dementia
* Other current or past brain condition
* severe head trauma
* epilepsy prior to stroke still requiring previous treatment
* Parkinson disease, multiple sclerosis...
* brain tumor or brain radiation therapy
* Current or past schizophrenia or psychosis
* Active or past psychiatric disorders requiring a stay\> 2 days in a specialized environment
* Contra indication to MRI
* Comorbidity with life expectancy \<1 year
* Comorbidity affecting cognition in particular:
* Alcohol (\> 3 glasses / day) or history of alcohol withdrawal syndrome
* opiate or cocaine addiction or opiate withdrawal syndrome
* renal failure (dialysis or creatinine clearance \<30)
* hepatic failure (spontaneous INR\> 1.5 or PT \<60%)
* respiratory failure requiring oxygen therapy
* heart failure (orthopnea\> 2 pillows)
* persistent vigilance disturbances (NIHSS1a score ≤1)
* cancer with paraneoplastic syndrome
* treatment with gold salts, D Penicillamine or other treatment with cognitive effect
* Patient under guardianship or curators or private under public law
* Pregnant and / or lactating wom

Where it's running

• CHU Amiens
  Amiens, France Recruiting

Study contacts

• Study coordinator: Martine ROUSSEL, PhD
• Email: roussel.martine@chu-amiens.fr
• Phone: 0322667813

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Motor learning with physical activity and advanced devices in healthy people and movement disorders

  This study tests whether combining traditional physical activity with advanced devices and immersive therapy helps improve motor skills and functional recovery in healthy individuals and people with movement disorders.

  Recruiting IRCCS Centro Neurolesi Bonino Pulejo · Messina, Italy/Me · NCT07066137

• Deep phenotyping to explore recovery in young adults after stroke

  This project will test whether a detailed health and sample-collection approach (deep phenotyping) is practical and acceptable for people aged 18–55 who have had a stroke.

  Recruiting The Florey Institute of Neuroscience and Mental Health · Heidelberg, Victoria and 1 other locations · NCT07019493

• Stem cell therapy for chronic stroke recovery

  This study is testing whether using a patient's own stem cells can help people with long-term stroke recovery feel better and improve their daily functioning.

  Recruiting Phase 2 Hokkaido University Hospital · Sapporo, Hokkaido · NCT06752720

• Longitudinal study on brain health and risk factors for neurological diseases

  This study is trying to understand how different health factors affect brain health over time in people who are at risk for conditions like stroke and dementia.

  Recruiting at 2 sites Chinese University of Hong Kong · Hong Kong and 1 other locations · NCT03592563

• Treatment for neurologic disorders using stem cells

  This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.

  Recruiting at 3 sites MD Stem Cells · Westport, Connecticut and 2 other locations · NCT02795052

• AI-based tools to help diagnose, treat and predict stroke outcomes across multiple hospitals

  This study tests AI-powered tools on real-world stroke patients to see if they can improve pre-hospital triage, diagnosis, and outcome prediction while data stay securely within each hospital.

  Recruiting at 2 sites Hospital Universitari Vall d'Hebron Research Institute · Leuven and 6 other locations · NCT07924371

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.