Assessing quality of life in patients with specific heart conditions
A Prospective Study to Assess Multi-Domain Patient-Reported Cardiac Quality of Life in Adults With Hypertrophic Cardiomyopathy, Thoracic Aortopathy, and Radiation-Induced Heart Disease: UPLIFT
The Cleveland Clinic · NCT04080492
This study looks at how living with certain heart conditions affects the quality of life for adults who can't have surgery, to see what factors might influence their health and well-being over time.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 1200 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | The Cleveland Clinic (other) |
| Drugs / interventions | radiation |
| Locations | 1 site (Cleveland, Ohio) |
| Trial ID | NCT04080492 on ClinicalTrials.gov |
What this trial studies
This observational cohort study aims to evaluate the quality of life in adult patients diagnosed with hypertrophic cardiomyopathy, thoracic aortic dilatation, or radiation-induced heart disease who are not candidates for surgery. Conducted at the Cleveland Clinic, participants will complete a Cardiac Quality of Life Survey at three different time points to measure their health status across various domains, including physical, emotional, and social well-being. The study seeks to identify risk factors affecting quality of life and track changes over time, providing valuable insights for better disease management.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18-70 with a confirmed diagnosis of hypertrophic cardiomyopathy, thoracic aortic dilatation, or radiation-induced heart disease who are being evaluated at the Cleveland Clinic.
Not a fit: Patients who have previously undergone surgery or have plans for surgery within the next nine months will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved management strategies for patients with chronic heart conditions, enhancing their quality of life.
How similar studies have performed: While there is limited research specifically addressing quality of life in these conditions, similar studies have shown the importance of understanding patient-reported outcomes in chronic diseases.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients aged 18-70 at time of consent with a confirmed diagnosis of HCM, TAD, and/or RIHD being seen at CC Main Campus for a comprehensive clinical cardiac evaluation (i.e. physician, surgeon, nurse practitioner, geneticist, testing, imaging, etc) to define treatment plan for either diagnosis as per Cleveland Clinic provider. * Patient or an individual in their social support network has the equipment (phone, computer, tablet) and internet connection to complete the emailed follow-up questionnaires. Exclusion Criteria: * Previously had surgery or plans to have surgery (full/mini sternotomy or endovascular) in the next nine months for HCM or TAD. * Inability or unwillingness to comply with study requirements in the opinion of the investigator. * Inability to provide informed consent.
Where this trial is running
Cleveland, Ohio
- Cleveland Clinic — Cleveland, Ohio, United States (RECRUITING)
Study contacts
- Principal investigator: Milind Desai, M. D. — The Cleveland Clinic
- Study coordinator: Milind Desai, M. D.
- Email: desaim2@ccf.org
- Phone: 216-445-5250
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Hypertrophic Obstructive Cardiomyopathy, Thoracic Aortic Dilatation, Heart Disease Caused by Ionising Radiation, Quality of Life