Assessing PYLARIFY PET-CT for detecting metastasis in certain cancers

A Pilot Study to Assess the Clinical Utility of PYLARIFY PET-CT for Detecting Metastasis in Pancreatic Cancer, Hepatocellular Carcinoma and Breast Cancer

This study is testing if a new type of PET-CT scan called PYLARIFY can help find cancer spread in people with pancreatic, liver, or breast cancer.

Quick facts

• Phase: Phase 1
• Study type: Interventional
• Enrollment: 36 (estimated)
• Ages: 18 Years and up
• Sex: All
• Sponsor: M.D. Anderson Cancer Center (Academic / other)
• Drugs / interventions: chemotherapy, immunotherapy, radiation
• Locations: 1 site (Houston, Texas)
• Trial ID: NCT05394259 on ClinicalTrials.gov

What this trial studies

This pilot study aims to evaluate the diagnostic accuracy of PYLARIFY (piflufolastat F18) PET-CT imaging in patients with suspected metastatic pancreatic cancer, hepatocellular carcinoma (HCC), and breast cancer. The primary objective is to compare the results of PYLARIFY PET-CT scans with established diagnostic standards to determine its effectiveness. Secondary objectives include assessing additional accuracy metrics such as sensitivity and specificity, as well as evaluating the clinical utility of the imaging technique in guiding treatment decisions.

Who should consider this trial

Good fit: Ideal candidates include adults aged 18 and older with confirmed pancreatic ductal adenocarcinoma, HCC, or invasive lobular carcinoma who have suspected or proven metastatic disease.

Not a fit: Patients under 18 years of age or those without measurable lesions on standard imaging modalities will not benefit from this study.

Why it matters

Potential benefit: If successful, this study could enhance the accuracy of metastatic cancer detection, leading to improved treatment strategies for patients.

How similar studies have performed: Other studies have shown promising results with similar imaging approaches, indicating potential for success in this novel application.

Eligibility criteria

Inclusion Criteria:

1. Age ≥18 years. Because no dosing or adverse event data are currently available on the use of PYLARIFY in patients \<18 years of age, children are excluded from this study.
2. ECOG performance status ≤2 (Karnofsky ≥60%,).
3. Subject or subject's Legally Authorized Representative (LAR) is able to understand, willing and able to provide written informed consent.
4. Patients must have histologically or cytologically confirmed pancreatic ductal adenocarcinoma, HCC and invasive lobular carcinoma
5. Patients with either: a) clinical or radiological (SoC CT, or MRI or FDG PET-CT tests) suspicion of metastatic disease; or b) proven metastatic disease but in whom there is suspicion of an even greater tumor burden that could change therapy approach.
6. Patients with at least one measurable lesion on SoC imaging modality (CT, or MRI, or FDG PET-CT).

   Patients must have measurable disease, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions and short axis for nodal lesions) as ≥20 mm (≥2 cm) by chest x-ray or as ≥10 mm (≥1 cm) with CT scan, MRI, or calipers by clinical exam.
7. Ability and willingness to undergo biopsy if needed per standard of care for possible metastasis which could change therapy approach. Subject requires further confirmatory diagnostic procedures to confirm PYLARIFY (piflufolastat F18)-PET-CT findings and is planned for: a) Biopsy as SoC; or b) Clinical follow- up as SoC.
8. Either: a) treatment naïve; or b) in active treatment but with suboptimal clinical outcome/response, as determined by treating physicians, and with SoC plan to further biopsy suspected metastatic lesions, PYLARIFY (piflufolastat F18) PET- CT can be performed at least 1 day prior to the planned biopsy.
9. Estimated life expectancy of at least 3 months as determined by the Investigator or treating physician.

Exclusion Criteria:

1. Pregnant or breastfeeding during participation in the study are excluded because: There is no information on the risk of adverse developmental outcomes in pregnant women or animals with the use of piflufolastat F18. All radiopharmaceuticals, including PYLARIFY, have the potential to cause fetal harm depending on the fetal stage of development and the magnitude of the radiation dose; There is no information on the presence of piflufolastat F18 in human milk, the effect on the breastfed infant, or the effect on milk production.
2. History of allergic reactions to PSMA PET radiopharmaceuticals.
3. Patients with psychiatric illness/social situations that would limit compliance with study requirements.
4. Unable to lie flat during or tolerate PET-CT
5. Patients who have had chemotherapy, immunotherapy or radiotherapy within 4 weeks prior to PYLARIFY (piflufolastat F18) injection.
6. Contraindications to PYLARIFY Injection have not been established in humans. None are known or have been observed in nonclinical or clinical studies performed to date. As indicated FDA product labels: Androgen deprivation therapy (ADT) and other therapies targeting the androgen pathway, such as androgen receptor antagonists, may result in changes in uptake of PYLARIFY in prostate cancer. The effect of these therapies on performance of PYLARIFY PET has not been established.
7. Subjects with any medical condition or circumstance that the investigator believes may compromise the safety or compliance of the subject to produce reliable data or completing the study.
8. Patients with other types of pancreatic, hepatic or breast neoplasms will be excluded

Where this trial is running

Houston, Texas

• MD Anderson Cancer Center — Houston, Texas, United States (Recruiting)

Study contacts

• Principal investigator: Yang Lu, MD, PHD — M.D. Anderson Cancer Center
• Study coordinator: Yang Lu, MD, PHD

Conditions Pancreatic Cancer; Breast Cancer; Hepatocellular Carcinoma