Assessing postural stability changes in Parkinson's patients using high frequency TMS
The Long Term Efficacy of High Frequency Repetitive Transcranial Magnetic Stimulation on Postural Stability in Parkinsonian Patients.
This study is testing if adding a special brain treatment called rTMS to physical therapy can help people with Parkinson's disease improve their balance and reduce their chances of falling.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 55 Years to 70 Years |
| Sex | Male |
| Sponsor | Cairo University Academic / other |
| Locations | 1 site (Giza, Ad Doqi, Giza District, Giza Governorate) |
| Trial ID | NCT05198076 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the long-term effects of high frequency repetitive transcranial magnetic stimulation (rTMS) on postural stability in patients with Parkinson's disease. Thirty to forty participants will be randomly assigned to either a control group receiving physical therapy or a study group receiving rTMS in addition to physical therapy. The treatment will consist of 12 sessions over four weeks, with assessments conducted before treatment, after treatment, and one month later using the Biodex balance system. The goal is to determine if rTMS can significantly improve balance and reduce the risk of falls in these patients.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 55-70 with mild to moderate Parkinson's disease, diagnosed according to U.K. Parkinson's Disease Brain Bank Criteria.
Not a fit: Patients with severe symptoms, such as severe freezing or tremors, or those with implanted devices or serious medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could enhance postural stability and reduce fall risk in patients with Parkinson's disease.
How similar studies have performed: While the use of rTMS in Parkinson's disease is being explored, this specific approach to improving postural stability is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * All included patients should fulfill the U.K Parkinson's Disease Brain Bank Criteria for idiopathic PD. * Patients with mild to moderate disease severity according to UPRS and Modified Hoehn and Yahr staging * Duration of illness from two to five years were included. * All included patients should be medically and psychologically stable and of adequate cardiac function. * All included patients should haven't receive any rTMS sessions before. * Signed consent form should be taken from all included patients. Exclusion Criteria: * Patients with implanted devices, serious medical illness or history of seizures were excluded. * Patients with severe freezing phenomenon or severe tremors were excluded
Where this trial is running
Giza, Ad Doqi, Giza District, Giza Governorate
- Faculty of Physical Therapy, Cairo University — Giza, Ad Doqi, Giza District, Giza Governorate, Egypt (Recruiting)
Study contacts
- Principal investigator: Engy BadrEldin S Moustafa, PhD — Cairo University
- Study coordinator: Engy BadrEldin S Moustafa, PhD
- Email: engybm.saleh@cu.edu.eg
- Phone: 00201099445112
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.