Assessing platelet function and neurological events in stroke patients undergoing carotid surgery
Platelet Function and Neurological Events Following Carotid Thromboendarterectomy
This study is testing how changes in blood platelets might affect the risk of brain problems in stroke patients having carotid surgery.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 386 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Scientific Institute San Raffaele Academic / other |
| Locations | 1 site (Milan) |
| Trial ID | NCT05572320 on ClinicalTrials.gov |
What this trial studies
This observational study aims to evaluate the correlation between platelet function, measured by impedance aggregometry, and neurological events in patients undergoing carotid thromboendarterectomy (TEA). The study focuses on understanding how variations in platelet function may contribute to the risk of transient or permanent neurological injuries during and after the procedure. By analyzing data from patients who are already on antiplatelet therapy, the research seeks to provide insights into the role of platelet activity in stroke prevention and management. The findings could help refine patient care strategies in vascular surgery.
Who should consider this trial
Good fit: Ideal candidates for this study are adults over 18 years old with carotid artery diseases who are scheduled for carotid thromboendarterectomy.
Not a fit: Patients with atrial fibrillation, those on new oral anticoagulants, or those with ongoing ischemic strokes may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved risk assessment and management strategies for patients undergoing carotid surgery, potentially reducing the incidence of neurological events.
How similar studies have performed: While there is existing evidence linking platelet function to neurological events in similar contexts, this specific approach using impedance aggregometry in carotid TEA patients is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age \> 18 years * Carotid Artery Diseases undergoing carotid thrombendarterectomy * Signed consent Exclusion Criteria: * Atrial fibrillation * New oral anticoagulant * Oral Vitamin k inhibitors * Platelet count \<80000 per microliter * Ongoing ischemic stroke
Where this trial is running
Milan
- Scientific Institute San Raffaele — Milan, Italy (Recruiting)
Study contacts
- Principal investigator: Fabrizio Monaco, MD — San Raffaele Scientific Institute
- Study coordinator: Fabrizio Monaco, MD
- Email: monaco.fabrizio@hsr.it
- Phone: +39223467176
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.