Assessing Placental Blood Flow in Pregnant Women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the flow of oxygen and blood necessary for nutrient transfer across the placenta during the second and third trimesters in women who are obese compared to those with average weight before pregnancy. Using functional Magnetic Resonance Imaging (fMRI) with arterial spin labeling (ASL), the study aims to identify differences in placental oxygenation and blood flow. Participants will undergo MRI scans in both the second and third trimesters to assess placental perfusion and its implications for pregnancy outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Singleton pregnancy, less than 24 weeks gestation
* Pre-pregnancy BMI between 18.5 - 24.9kg/m2 or ≥30kg/m2

Exclusion Criteria:

* Asthma on controller medication
* Autoimmune Conditions
* Chronic Hypertension
* Claustrophobia
* Congenital Anomaly
* Pregestational Diabetes
* History of Bariatric Surgery
* HIV
* Ineligible for MRI (incompatible implanted medical device)
* Multifetal Gestation
* Smoking during pregnancy

Where it's running

• Endeavor Health
  Evanston, Illinois, United States Recruiting

Study contacts

• Principal investigator: Caitlin MacGregor — Endeavor Health
• Study coordinator: Alexandra Mangus
• Email: alexandra.mangus@endeavorhealth.org
• Phone: (847) 570-2243

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.