Assessing PEEP effects on obese patients during laparoscopic surgery
Official title: Recruitment-to-inflation Ratio to Set Positive End-expiratory Pressure for Laparoscopic/Robotic Surgery: a Multicenter Study
Run by Azienda Ospedaliera di Perugia · NCT05702554 · Data updated 2026-05-14
This study is no longer in our active list. It may have stopped recruiting or finished. The details below are as of 2026-05-14 and are kept for reference. Check ClinicalTrials.gov for its current status, or see similar studies below.
This study is testing how different levels of breathing support can help obese patients breathe better during laparoscopic surgery.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 50 (estimated) |
| Sponsor | Azienda Ospedaliera di Perugia Academic / other |
| Locations | 2 sites (Perugia, Umbria, Italy and 1 other locations) |
| Trial ID | NCT05702554 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult obese patients with a BMI of 30 kg/m2 or higher scheduled for laparoscopic or robotic surgery requiring invasive mechanical ventilation.
✕Probably not a fit
Patients with severe comorbidities such as ASA score ≥ 4 or chronic respiratory conditions may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This investigation evaluates the impact of positive end-expiratory pressure (PEEP) on respiratory system compliance in obese patients undergoing invasive mechanical ventilation for laparoscopic or robotic surgery with pneumoperitoneum. Adult patients with a body mass index of 30 kg/m2 or higher will be enrolled after providing informed consent. The study will involve the application of different PEEP levels based on the recruitment-to-inflation ratio to optimize respiratory mechanics during surgery. Exclusion criteria include severe comorbidities that may affect respiratory function.
Why it matters
Potential benefit: If successful, this study could improve respiratory management and outcomes for obese patients undergoing laparoscopic surgery.
How similar studies have gone: While similar approaches have been explored, this specific methodology focusing on PEEP adjustment in obese patients during laparoscopic surgery is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult obese (body mass index ≥ 30 kg/m2) patients undergoing invasive mechanical ventilation for laparoscopic or robotic surgery with pneumoperitoneum will be enrolled, upon the acquisition of informed consent. Exclusion Criteria: * Will be excluded all the patients with the following conditions: american society of anesthesiologists (ASA) score ≥ 4; severe cardiopathy, intracranial hypertension, tracheosthomy, previous cardio-thoracic surgery, pulmonary hypertrension, broncho-pleural fistula, pulmonary emphysema, pnumothorax, chronic respiratory failure, chronic obstructive pulmonary disease, pregnancy.
Where it's running
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Università degli Studi di Perugia
Perugia, Umbria, Italy, Italy Recruiting -
Università degli Studi di Perugia
Perugia, Italy Recruiting
Similar studies
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.