Assessing pancreas changes during pregnancy
Diabetes Prediction During Pregnancy Using Pancreas MRI
This study is testing how the size of the pancreas changes during pregnancy in women and their babies, especially looking at the effects of diabetes.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 87 (estimated) |
| Ages | 18 Years to 54 Years |
| Sex | Female |
| Sponsor | University of Texas at Austin Academic / other |
| Locations | 1 site (Austin, Texas) |
| Trial ID | NCT06784674 on ClinicalTrials.gov |
What this trial studies
The MAMA study is a prospective cohort study that investigates how pancreas size changes during pregnancy in women and their infants, particularly focusing on the impact of maternal diabetes. It will follow pregnant women aged 18-54 who are under 14 weeks gestation and their babies through pregnancy and one year postpartum. Participants will undergo various assessments including MRI scans, blood tests, and glucose monitoring at multiple points during and after pregnancy to gather data on pancreas size and its relationship with gestational diabetes and infant development.
Who should consider this trial
Good fit: Ideal candidates are pregnant women aged 18-54 with a singleton gestation who are under 14 weeks pregnant.
Not a fit: Patients with mechanically or magnetically activated implants, claustrophobia, or a BMI of 35 or higher may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of gestational diabetes and improve maternal and infant health outcomes.
How similar studies have performed: While there have been studies on pancreas size and diabetes, this specific approach of monitoring changes during pregnancy is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women, with a singleton gestation * Age 18 - 54 years at screening * Gestational age \< 14 weeks * Willing to commit to 1 year postpartum follow up * Planning to remain in geographical vicinity of Austin for 1 year after delivery Exclusion Criteria: * Presence of any mechanically or magnetically activated implants * Claustrophobia * Other contraindication for MRI * BMI ≥ 38.0 or maximum width less than 48 cm (necessary to fit within the MRI field of view)
Where this trial is running
Austin, Texas
- Dell Medical School Health Discovery Building — Austin, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Jack Virostko, Ph.D. — University of Texas at Austin
- Study coordinator: Jack Virostko, Ph.D.
- Email: jack.virostko@austin.utexas.edu
- Phone: 512-495-5126
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.