Assessing minimal doses of muscle relaxant during general anesthesia
Respiratory Benefits of Small Doses Muscle Relaxant in General Anesthesia
NA · Mansoura University · NCT04344262
This study tests if using lower doses of a muscle relaxant during surgery can help adults recover better and breathe easier afterwards.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 20 Years to 50 Years |
| Sex | All |
| Sponsor | Mansoura University (other) |
| Locations | 1 site (Al Mansurah) |
| Trial ID | NCT04344262 on ClinicalTrials.gov |
What this trial studies
This study evaluates the effects of minimal doses of muscle relaxant on postoperative pulmonary function in adult patients undergoing non-cardiothoracic surgery. Participants will be randomly assigned to receive either a standard or a minimal dose of atracurium, with the primary outcome being the time to extubation as an indicator of muscle recovery. Additional assessments will include intraoperative surgical conditions, postoperative complications, and lung function using ultrasound and spirometry. The goal is to determine if lower doses can maintain adequate surgical conditions while improving recovery outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 20 to 50 scheduled for non-cardiothoracic surgery under general anesthesia.
Not a fit: Patients with significant comorbidities, such as severe lung, renal, or hepatic diseases, or those requiring profound muscle relaxation will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to faster recovery times and improved pulmonary function for patients after surgery.
How similar studies have performed: While similar approaches have been explored, this specific method of using minimal doses of muscle relaxants in this context is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients * aged from 20 to 50 years old * scheduled for non-cardiothoracic surgery * under general anesthesia * in supine position * after informed consent Exclusion Criteria: * American Society of Anesthesiologists (ASA) score more than 3 * suspected full stomach or who will undergo intervention expected to necessitate profound muscle relaxation or dressing interferes with ultrasound (US) probe positioning * Lung parenchymatous disease * renal disease * hepatic disease * neuromuscular disease * electrolytes imbalanc * on medication interfere with muscle contraction * with known allergy to any drug used in the study
Where this trial is running
Al Mansurah
- Mansoura University-Emergency hospital-ICU — Al Mansurah, Egypt (RECRUITING)
Study contacts
- Study coordinator: Maha Ahmed Abo-Zeid, MD
- Email: mahazed@mans.edu.eg
- Phone: 02-01019216192
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Muscle Relaxant