Assessing minimal doses of muscle relaxant during general anesthesia
Official title: Respiratory Benefits of Small Doses Muscle Relaxant in General Anesthesia
Run by Mansoura University · NCT04344262 · Data updated 2026-11-12
This study tests if using lower doses of a muscle relaxant during surgery can help adults recover better and breathe easier afterwards.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 20 Years to 50 Years |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Mansoura University Academic / other |
| Locations | 1 site (Al Mansurah) |
| Status | Recruiting |
| Started | April 22, 2020 |
| Main results expected | December 30, 2029 |
| Study ends | June 30, 2030 |
| Registry record updated | October 15, 2026 |
| Trial ID | NCT04344262 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 20 to 50 scheduled for non-cardiothoracic surgery under general anesthesia.
✕Probably not a fit
Patients with significant comorbidities, such as severe lung, renal, or hepatic diseases, or those requiring profound muscle relaxation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study evaluates the effects of minimal doses of muscle relaxant on postoperative pulmonary function in adult patients undergoing non-cardiothoracic surgery. Participants will be randomly assigned to receive either a standard or a minimal dose of atracurium, with the primary outcome being the time to extubation as an indicator of muscle recovery. Additional assessments will include intraoperative surgical conditions, postoperative complications, and lung function using ultrasound and spirometry. The goal is to determine if lower doses can maintain adequate surgical conditions while improving recovery outcomes.
Why it matters
Potential benefit: If successful, this approach could lead to faster recovery times and improved pulmonary function for patients after surgery.
How similar studies have gone: While similar approaches have been explored, this specific method of using minimal doses of muscle relaxants in this context is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients * aged from 20 to 50 years old * scheduled for non-cardiothoracic surgery * under general anesthesia * in supine position * after informed consent Exclusion Criteria: * American Society of Anesthesiologists (ASA) score more than 3 * suspected full stomach or who will undergo intervention expected to necessitate profound muscle relaxation or dressing interferes with ultrasound (US) probe positioning * Lung parenchymatous disease * renal disease * hepatic disease * neuromuscular disease * electrolytes imbalanc * on medication interfere with muscle contraction * with known allergy to any drug used in the study
Where it's running
-
Mansoura University-Emergency hospital-ICU
Al Mansurah, Egypt Recruiting
Study contacts
- Study coordinator: Maha Ahmed Abo-Zeid, MD
- Email: mahazed@mans.edu.eg
- Phone: 02-01019216192
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.