Assessing lung cancer risk factors and early detection methods
Lung Cancer Risk Assessment &Amp; Etiology
This study is trying to find out what factors might increase the risk of lung cancer in both smokers and non-smokers, and how to better detect it early by collecting information through surveys, blood samples, and low-dose CT scans.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 200 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | City of Hope Medical Center Academic / other |
| Locations | 1 site (Duarte, California) |
| Trial ID | NCT06328621 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the biological and social determinants that may increase the risk of lung cancer in both patients and never-smokers. It aims to assess the frequency of genetic mutations associated with lung cancer risk and explore the relationship between social determinants of health and lung cancer incidence. Participants will complete a survey, provide blood samples, and undergo low-dose CT scans if they are unaffected by lung cancer. The study seeks to enhance early detection strategies for lung cancer through comprehensive data collection and analysis.
Who should consider this trial
Good fit: Ideal candidates include individuals with a personal or family history suggestive of high lung cancer risk, including never-smokers with lung cancer or those with specific genetic alterations.
Not a fit: Patients without any family history of lung cancer or those who do not meet the inclusion criteria may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved early detection and prevention strategies for lung cancer.
How similar studies have performed: Other studies have shown success in identifying genetic risk factors and improving early detection methods for lung cancer, making this approach promising.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Have had clinical germline genetic testing and/or have consented or expressed a willingness to consent to the City of Hope (COH) General Research Protocol COH IRB # 07047 * Age \>= 18 years * Willing to have about 30 mL of blood (approximately 2 tablespoons) drawn during the aspiration visit * Speak English, Spanish, or Mandarin * Lung cancer patients: meeting at least one of the following criteria: * Be a never-smoker with lung cancer (excludes atypical/typical carcinoid and small cell tumors) * Be diagnosed with lung cancer =\< 50 years of age * Have a germline alteration known/suspected to be associated with elevated lung cancer risk * Have a strong family history of lung cancer (\>= one first, second or third degree relative with never-smoking lung cancer, \>= three first, second or third degree relative with lung cancer in one lineage \[side of the family\], \>= one first, second or third degree relative diagnosed with lung cancer under the age of 50. Patients may also be considered eligible if they meet the family history criteria in part and have a truncated family structure \[e.g., only one first and one second degree relative with lung cancer in a small family\]) * Unaffected patients (i.e., those without a lung cancer diagnosis and other cancer diagnosis for the past 5 years) who are at least 50 years of age or at most age 10 years younger than the first case of lung cancer in the family, meeting at least one of the following criteria: * Have a germline alteration known/suspected to be associated with elevated lung cancer risk * Have a strong family history of lung cancer (\>= one first, second or third degree relative with never-smoking lung cancer, \>= three first, second or third degree relative with lung cancer in one lineage \[side of the family\], \>= one first, second or third degree relative diagnosed with lung cancer under the age of 50. Patients may also be considered eligible if they meet the family history criteria in part and have a truncated family structure \[e.g., only one first and one second degree relative with lung cancer in a small family\]) * Of East Asian descent with any family history of lung cancer * Documented informed consent of the participant Exclusion Criteria: * Unable to provide informed consent * Patients who fall under the unaffected cohort criteria but received chest imaging (except chest x-ray) within the last year
Where this trial is running
Duarte, California
- City of Hope Medical Center — Duarte, California, United States (Recruiting)
Study contacts
- Principal investigator: Stacy W Gray — City of Hope Medical Center
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.