Assessing liver stiffness measurements in chronic viral hepatitis patients
Official title: Agreement and Reliability of Transient Elastography in Patients With Chronic Viral Hepatitis - a Cross-sectional Test-retest Study
Run by Lund University · NCT05686785 · Data updated 2026-11-12
This study is testing how reliable and consistent liver stiffness measurements are in people with chronic viral hepatitis using a special ultrasound technique.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | Lund University Academic / other |
| Locations | 1 site (Helsingborg, Skåne County) |
| Status | Recruiting |
| Started | June 1, 2023 |
| Main results expected | February 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | October 4, 2023 |
| Trial ID | NCT05686785 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adult patients with chronic viral hepatitis who can provide informed consent and communicate in Swedish.
✕Probably not a fit
Patients who are pregnant, unable to speak Swedish, or cannot provide informed consent will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the agreement, smallest detectable change, and reliability of repeated liver stiffness measurements using transient elastography in patients with chronic viral hepatitis. It will explore factors that may contribute to discrepancies in measurements. By focusing on the reliability and agreement metrics, the study seeks to provide a clearer understanding of how transient elastography performs in this patient population, which has not been thoroughly addressed in previous research.
Why it matters
Potential benefit: If successful, this study could enhance the accuracy and reliability of liver stiffness assessments, leading to better management of chronic viral hepatitis.
How similar studies have gone: Previous studies have shown excellent test-retest reliability for transient elastography in viral hepatitis, but this study addresses gaps in agreement metrics and smallest detectable change, making it a novel approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients at the departments of infectious diseases in Malmö, Lund and Helsingborg with chronic viral hepatitis. * Adult patients * Signed informed consent to participate in the study. Exclusion Criteria: * suspected or confirmed pregnancy. * patients unable to speak Swedish * inability to sign informed consent.
Where it's running
-
Oskar Ljungquist
Helsingborg, Skåne County, Sweden Recruiting
Study contacts
- Principal investigator: Oskar Ljungquist, MD, PhD. — Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund.
- Study coordinator: Oskar Ljungquist, M.D, PhD
- Email: oskar.ljungquist@med.lu.se
- Phone: +46424061000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Simultaneous hepatitis B, C and HIV screening with rapid tests and FibroScan for people who use drugs and other vulnerable adults outside hospitals
This project will try offering rapid blood tests and on-site FibroScan to find hepatitis B, C and HIV and quickly link people who use drugs and other vulnerable adults to care.
-
Comparing Tenofovir Alafenamide and Entecavir for Chronic Hepatitis B Treatment
This study is testing whether a newer hepatitis B medication called tenofovir alafenamide works as well as an older one called entecavir, while also being safer for the kidneys.
-
Creating biological models to study liver diseases and tumors
This study is trying to create new models to better understand liver diseases and tumors so that we can find better treatments for people suffering from these conditions.
-
Impact of functional cure on patient-reported outcomes in chronic hepatitis B
This study tests whether people with chronic hepatitis B who achieve a functional cure have better patient-reported outcomes compared to those not cured, relapse, or healthy controls.
-
Sequential combination therapy for functional cure of chronic hepatitis B
This trial tests a new two-drug approach to see if adding immunotherapy to ongoing HBV treatment can lead to loss of hepatitis B surface antigen in adults with chronic hepatitis B.
-
Combination therapy for functional cure in chronic hepatitis B
This phase 2 trial tests whether a sequence of anti-PD-1/PD-L1 antibodies with pegylated interferon and nucleos(t)ide analogues can achieve functional cure (HBsAg loss) in adults with chronic hepatitis B.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.