Assessing liver cancer risk in patients with chronic liver disease using advanced MRI techniques

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study utilizes multi-parameter magnetic resonance imaging (MRI) techniques, including T1 mapping, T2 mapping, T1ρ, and elastography, to quantitatively assess the risk of hepatocellular carcinoma (HCC) in patients with cirrhosis. It involves both retrospective and prospective data collection from patients, who will be monitored over a five-year period to determine the development of liver cancer. The study aims to compare clinical characteristics, laboratory tests, and imaging parameters between patients who develop HCC and those who do not, ultimately creating a predictive nomogram for HCC risk based on these variables.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* 1\. Aged over 18 years old; 2. Liver function Child-Pugh classification A or B; 3. Patients with chronic liver disease who meet the diagnostic criteria for high-risk groups of liver cancer in the "Guidelines for the Diagnosis and Treatment of Primary Liver Cancer (2022 Edition)"; 4. Equipped with Gd-EOB-DTPA enhanced MRI scan images, including T1 mapping, T2 mapping, T2\* mapping, T1ρ and other sequences; 5. With 5-year follow-up data.

Exclusion Criteria:

* 1\. Patients who are unable to undergo MRI scanning due to claustrophobia, abnormal renal function, etc.; 2. Patients who have undergone liver surgery in the past; 3. Patients with major diseases such as heart failure and tumors.

Where it's running

• Yaqin, Zhang
  Zhuhai, Guangdong, China Recruiting

Study contacts

• Study coordinator: Yaqin Zhang, MD, Ph.D
• Email: zhyaqin@mail.sysu.edu.cn
• Phone: 13719282895

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.